Definition
The term "endometritis" indicates an inflammatory pathology on an infective basis, which affects the endometrium, ie the mucosa that covers the uterus internally.
This type of inflammation occurs mainly in the immediate post-partum, but there is still the possibility that endometritis occurs even in women who have not yet given birth and in menopausal women. In this regard, we can distinguish two forms of endometritis: acute endometritis (typical of post-partum) and chronic endometritis (typical in women outside the gestational period).
Causes
Endometritis is caused by a bacterial infection, which can be sustained by microorganisms of different nature, such as: Gram-positive (such as streptococci and staphylococci), gram-negative (such as, for example, Escherichia coli, Klebsiella spp., Etc. .), anaerobic bacteria (such as, for example, Bacteroides spp.) and other pathogens such as Mycoplasma spp, Ureaplasma spp., etc.
Symptoms
The main symptoms induced by endometritis are: uterine bleeding, menorrhagia, uterine discharge, pain during sexual intercourse, abdominal bloating, headache, fever and generalized weakness.
Furthermore, the infection can expand and reach the myometrium, in these cases, it is also common to feel a sensation of pain.
Information on Endometritis - Drugs for Endometritis Care is not intended to replace the direct relationship between health professional and patient. Always consult your doctor and / or specialist before taking Endometritis - Endometritis Drugs.
drugs
Generally, the treatment of endometritis can be effected effectively through the administration of antibiotic drugs. In fact, in most cases, symptoms are resolved within 48-72 hours of starting treatment.
The antibiotics that are usually used are broad spectrum; if, on the other hand, it was possible to identify the microorganism responsible for the inflammation, then the doctor may decide to establish a more targeted and specific therapy.
Doxycycline
Doxycycline is an antibiotic belonging to the tetracycline class. It is one of the first-line drugs in the treatment of endometritis associated with chlamydia.
Doxycycline is available for oral administration in the form of tablets or capsules. The dose of drug usually used is 100-200 mg a day, to be taken with plenty of water at least an hour before bedtime (to avoid any esophageal irritation).
Clindamycin and Gentamicin
Generally, for the treatment of endometritis associated with chlamydia, clindamycin is administered parenterally in combination with gentamicin, but only when it is not possible to use the first choice antibiotics, ie tetracyclines.
Clindamycin (Dalacin ®, Cleocin ®, Clindamycin phosphate Hikma ®) is an antibiotic belonging to the class of lincosamides and available in the form of pharmaceutical formulations suitable for oral, vaginal and parenteral administration.
The dose of clindamycin usually used is 900 mg of drug per day, to be administered by intravenous infusion.
The dose of gentamicin (Gentalyn ®, Gentomil ®) usually used, instead, is 3-6 mg / kg of body weight, to be administered intravenously 1-2 times a day.
In any case, the doctor will determine for each patient the exact amount of drugs to be used, the frequency of administration and the duration of treatment.
Amoxicillin
Amoxicillin is an antibiotic belonging to the class of penicillins with a broad spectrum of action. Generally, in the treatment of uncomplicated endometritis, amoxicillin is administered in combination with gentamicin and metronidazole.
It is a drug available in pharmaceutical formulations suitable for oral and parenteral administration. When administered via the latter route, the dose of medication usually used in adult patients is 500-1, 000 mg, to be administered by intramuscular or intravenous injection, or by intravenous infusion, every 8-12 hours.
In any case, the doctor will determine the exact amount of amoxicillin to use for each patient.
Metronidazole
Metronidazole (Deflamon ®) is a drug belonging to the class of nitroimidazole antibiotics. It is available in pharmaceutical formulations suitable for different administration routes: oral, vaginal and parenteral. When administered via the latter route, the dose of medication usually used in adults is 500 mg, to be taken every eight hours. However, it will be the doctor who will determine the exact dosage of medicine that each patient will have to take, also taking into account the fact that, as mentioned, in the treatment of endometritis this active ingredient can be used in combination with amoxicillin and gentamicin.
