GENTALYN ® Gentamicin

GENTALYN ® is a drug based on Gentamicin sulphate

THERAPEUTIC GROUP: Antibiotics for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications GENTALYN ® Gentamicin

GENTALYN ® is successfully used in the treatment of inflammatory skin lesions sustained by Gentamicin-sensitive microorganisms.

Folliculitis, pyoderma, traumatic lesions, ulcers, burns, excoriations and eczema are just some of the pathological conditions for which the use of GENTALYN ® is indicated.

Mechanism of action GENTALYN ® Gentamicin

Gentamicin, active ingredient of GENTALYN ®, is a natural aminoglycoside antibiotic extracted in the laboratory from bacterial cultures of Micromonospora purpurea effective against numerous Gram positive and negative microorganisms such as Staphylococcus aureus, Pseudomonas aeuriginosa, E.Coli, Proteus vulgaris generally responsible for skin infections and superinfections.

The aforementioned therapeutic activity is supported by an effective mechanism of action which involves the binding of Gentamicin to the 30S ribosomal subunit and the consequent block of the process of protein synthesis.

The absence of enzymatic factors and structural proteins that derives from this inhibition, induces the rapid death of the bacteria and the gradual remission of the complained symptomatology.

Everything is also facilitated by the excellent pharmacokinetic properties of Gentamicin used topically, which significantly reduce the systemic absorption of the drug so as to be completely insignificant.

Studies carried out and clinical efficacy

THE USE OF THE GENTAMINE IN THE DIABETIC FOOT

Expert Opin Drug Deliv. 2009 Jun; 6 (6): 639-42. doi: 10.1517 / 17425240902997919.

Experimental study that demonstrates the potential utility of Gentamicin in foam in reducing the risk of infection in diabetic foot ulcers, thus improving the clinical course of the disease.

TOPIC GENTAMINE AND RISK OF POST-SURGICAL INFECTION

Ann Thorac Surg. 2012 Dec; 94 (6): 2033-7. doi: 10.1016 / j.athoracsur.2012.07.044. Epub 2012 Sep 7.

Reser D, Rodriguez Cetina Biefer H, Plass A, Ruef C, Seifert B, Bettex D, Biaggi P, Falk V, Salzberg SP.

Study demonstrating the utility of Gentamicin topically used in reducing the risk of infections following reoperation for post-operative bleeding. These data are particularly important especially for thoracic surgery and intensive care departments, where the risk of post-operative infection is a serious problem.

THE GENTAMYCIN IN THE BACTERIA CONJUNCTIVITY

Zhonghua Yan Ke Za Zhi. 2008 Dec; 44 (12): 1098-102.

Recent study demonstrating the efficacy of Gentamicin, in a formulation suitable for ophthalmic use, in reducing the bacterial proliferation present in the conjunctival sac during bacterial conjunctivitis.

Method of use and dosage

GENTALYN ®

Topical cream with 0.1% Gentamicin;

0.1% Gentamicin ointment for dermal use.

Always under medical indication, it is generally recommended to apply the appropriate quantity of medicine directly on the region affected by the infection process 3-4 times a day in the initial phases, to reduce to 1-2 applications in the following period.

Generally it is preferred to use GENTALYN ® in cream in secreting inflammatory lesions, GENTALYN ® ointment in dry forms.

Warnings GENTALYN ® Gentamicin

In order to preserve the efficacy and safety of the treatment with GENTALYN ® the patient in therapy should respect some hygienic-sanitary rules such as:

thoroughly clean the area to be treated before each application;
clean hands thoroughly after each application;
avoid contact of the drug with eyes and mucous membranes;
avoid the application of the product on particularly large cutaneous areas obviously damaged;
avoid prolonged use of the drug to avoid the formation of drug-resistant microbial strains and the appearance of adverse reactions.
keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

Given the lack of studies able to best characterize the safety profile of Gentamicin used topically for fetal health, it is advisable to limit only to cases of real need the use of GENTALYN ® during pregnancy and the subsequent breastfeeding period.

Any use should be supervised periodically by your doctor.

Interactions

Although no known pharmacological interactions are known, it is advisable to avoid the simultaneous use of other neuro and nephrotoxic drugs.

Contraindications GENTALYN ® Gentamicin

The use of GENTALYN ® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients.

Undesirable effects - Side effects

The use of GENTALYN ®, generally well tolerated and without clinically relevant side effects, could sometimes lead to the appearance of local adverse reactions such as erythema and itching.

The side effects associated with allergic events are decidedly more rare.