DERMADEX ® Dexamethasone

DERMADEX ® is a drug based on dexamethasone valerate

THERAPEUTIC GROUP: Non-associated corticosteroids, dermatological preparations

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications DERMADEX ® Dexamethasone

DERMADEX ® is indicated in the treatment of contact dermatitis and inflammatory dermatoses sensitive to topical treatment with corticosteroids.

Mechanism of action DERMADEX ® Dexamethasone

DERMADEX ® is a medicinal specialty based on dexamethasone valerate, a synthetic corticosteroid used effectively in the treatment of dermatitis and inflammatory skin disorders sensitive to topical treatment with corticosteroids.

Applied topically, dexamethasone valerate is evenly distributed between the epidermis and dermis, being absorbed systemically in small quantities, although dependent on the integrity of the skin itself.

Here he is able to control the secretion of inflammatory mediators, inducing the expression of lipocortin protein useful in inhibiting the activity of phospholipase A2, an enzyme at the apex of the cascade of events that leads to the synthesis of prostaglandins and other molecules with of vasodilatory, edemigenic, pro-inflammatory and platelet aggregating activity.

This activity rapidly materializes into the clear and rapid improvement of the complained symptomatology.

Studies carried out and clinical efficacy

TOP DESAMETASONE AND IMPROVEMENT OF THE HEALTH CONDITIONS OF THE SCIATIC NERVE

Injury. 2013 Apr; 44 (4): 565-9. doi: 10.1016 / j.injury.2012.10.013. Epub 2012 Nov 3.

Experimental study conducted on rats that demonstrates that the treatment with dexamethasone can significantly improve the health condition of the sciatic nerve, experimentally damaged, resulting in a clear improvement of the clinical conditions of the guinea pig.

INTRAVITRAL PLANTS OF DESAMETASONE

Houses Ophthalmol Rep. 2013 Mar 25; 4 (1): 53-8. doi: 10.1159 / 000350544. Print 2013 Jan.

Innovative study demonstrating the efficacy of intravitreal dexamethasone implants in significantly improving retinal conditions affected by retinitis pigmentosa and ocular edema, thus ensuring an optimization of both histological features and the relative clinical picture.

DESAMETASONE IN THE TREATMENT OF ALOPECIA AREATA

Int J Trichology. 2013 Jan; 5 (1): 47-9. doi: 10.4103 / 0974-7753.114708.

Very interesting study that reports the effectiveness of pulsatile treatment with dexamethasone in a young woman suffering from Alopecia areata, thus significantly improving both the clinical picture and the quality of life of the affected patient.

Method of use and dosage

DERMADEX ®

Dermatology cream 0.10 g of dexamethasone per 100 g of drug.

Generally, always according to medical indications, two or three applications a day are recommended, directly on the region to be treated, taking care to gently massage the area to ensure complete absorption of the product.

Sometimes, depending on the severity of the clinical picture, the doctor could prescribe the application of this drug through occlusive bandages.

Warnings DERMADEX ® Dexamethasone

DERMADEX ® therapy should be preceded by a careful medical examination in order to clarify the origin of the lesions and any prescriptive appropriateness.

The patient should also comply with a series of hygiene and health regulations designed to limit the potential side effects of topical corticosteroid therapy and to optimize the effectiveness of the therapy itself.

Avoid contact of the drug with eyes and mucous membranes, use the occlusive bandage exclusively in the cases prescribed by the doctor, avoid the application of the medicine on large and severely damaged skin areas, avoid prolonged use of the drug, cleanse the hands thoroughly afterwards. each application and avoiding direct exposure to ultraviolet radiation are only the main precautions to be used.

It should also be remembered that the use of corticosteroids over time could lead to the appearance of adverse reactions, fortunately mainly local.

PREGNANCY AND BREASTFEEDING

Generally the use of DERMADEX ® during pregnancy and the subsequent period of breastfeeding is contraindicated except in cases where the potential benefits far outweigh the risks associated with the therapy itself.

Interactions

Although topical application of dexamethasone considerably limits the potential side effects of corticosteroid therapy, it should be remembered that cytochromial system inhibitors can increase the half-life of the proportion of the drug eventually absorbed.

Contraindications DERMADEX ® Dexamethasone

The use of DERMADEX ® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients, in patients suffering from serious bacterial and viral infections such as tuberculous, luetic and viral processes, acne rosacea, perioral dermatitis, perianal and genital itching and ulcers skin.

Undesirable effects - Side effects

Edema, pruritus, desquamation, skin atrophy, dry skin, vascular disorders, hypertrichosis and other local reactions are the main side effects of DERMADEX ® therapy.

Fortunately, systemic adverse reactions are rarer.