NIZORAL ® is a drug based on Ketoconazole
THERAPEUTIC GROUP: Antifungals for dermatological use - imidazole derivatives
IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects
Indications NIZORAL ® Ketoconazole
NIZORAL ® is indicated in the treatment of fungal infections of the scalp and skin, supported by microorganisms sensitive to Ketoconazole.
Mechanism of action NIZORAL ® Ketoconazole
NIZORAL ®, although apparently similar to a common shampoo, is a drug based on Ketoconazole, an active ingredient belonging to the category of antimicotics able to inhibit the replication of microorganisms such as dermatophytes, yeasts and fungi, some of which are involved in the genesis of dandruff and seborrheic dermatitis, inhibiting the synthesis of a key element for the structuring of the plasma membrane such as? ergosterol.
This inhibition determines on one hand the greater sensitivity of the cell to the chemical-physical variations of the external environment, on the other the accumulation of intermediate metabolites capable of inhibiting the vital functions of the cell.
The aforementioned activities are carried out relatively quickly and above all without the active principle being absorbed systemically, thus reducing the risk of both clinically relevant drug interactions and systemic side effects.
Studies carried out and clinical efficacy
NIZORAL IN PROPHYLAXIS OF SCALP LEATHER INFECTIONS
J Pediatr Pharmacol Ther. 2011 Jul; 16 (3): 199-203.
A study that demonstrates how the prophylactic use of ketoconazole-based shampoos can be effective in reducing the onset of tinea capitis in the African-American pediatric population at high risk of infection.
KETOCONAZOLE IN ASSOCIATION IN THE TREATMENT OF SEBORROCIC DERMATITIS
Br J Dermatol. 2011 Jul; 165 (1): 171-6.
Clinical trial that demonstrates how the use of Ketoconazole especially when combined with other active ingredients such as clobetasol can be significantly more effective in the treatment of moderate and severe seborrheic dermatitis.
KETOCONAZOLE IN THE TREATMENT OF VERSICOLOR PYTHRIASIS
Indian J Dermatol Venereol Leprol. 2003 Mar-Apr; 69 (2): 142-3.
Work carried out on patients suffering from pityriasis versicolor who demonstrated how the application of 2% ketoconazole shampoo can be effective, in just a few days of treatment, guaranteeing prompt remission of symptoms without clinically relevant side effects.
Method of use and dosage
NIZORAL ®
Shampoo for topical application on scalp and skin of 20 mg Ketoconazole per gram of product.
It is advisable to apply NIZORAL ® shampoo twice a week, taking care to let the drug work for about 3-5 minutes before rinsing.
The duration of the whole treatment could last from 2 to 4 weeks.
Warnings NIZORAL ® Ketoconazole
Although the use of NIZORAL ® proves to be safe and free of side effects, it would be advisable in any case to consult your doctor before use, and to take care to rinse thoroughly both the skin and the body regions, such as the hands, come into contact with the product.
Prolonged use of NIZORAL ® could lead to the appearance of sensitization phenomena, generally not very serious and transient.
PREGNANCY AND BREASTFEEDING
The absence of any type of absorption of the active ingredient allows the use of NIZORAL ® even during pregnancy and in the subsequent period of breastfeeding.
However, it is necessary to specify the absence at the time of studies able to characterize the safety profile of the drug for the health of the fetus and the unborn child.
Interactions
No clinically relevant drug interactions are currently known.
Contraindications NIZORAL ® Ketoconazole
NIZORAL ® is contraindicated in patients who are hypersensitive to the active substance or to one of its excipients.
Undesirable effects - Side effects
The use of NIZORAL ® is generally safe and has no clinically noteworthy side effects.
Irritations, pruritus and hypersensitivity reactions at the site of administration are the most frequently observed adverse reactions.
Note
NIZORAL ® is a non-compulsory prescription drug and can therefore be sold freely
NIZORAL ® is also available in dermatological cream for vaginal pathologies, creams and solutions for vaginal use useful in the treatment of gynecological infections sustained by Candida.
