BEBEN ® Betamethasone

BEBEN ® is a drug based on Betamethasone 17-benzoate

THERAPEUTIC GROUP: Non-associated corticosteroids, dermatological preparations

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications BEBEN ® Betamethasone

BEBEN ® is indicated in the treatment of inflammatory and allergic skin conditions such as eczematous dermatitis, dermatitis due to physical agents, psoriasis, lichen ruber planus and intertrigo.

Mechanism of action BEBEN ® Betamethasone

Betamethasone 17-benzoate, active ingredient of BEBEN ®, is a synthetic corticosteroid with long activity, excellent bioavailability, high therapeutic efficacy and more contained side effects than other corticosteroids such as halogenated ones.

Applied topically, this active ingredient is distributed between the various layers of the epidermis to the superficial layer of the dermis, where it performs its therapeutic action by penetrating into the cytosol of the various cells and regulating the expression of different genes involved in the inflammatory cascade.

More precisely, corticosteroids are able to induce the expression of a mediator, known as Lipocortin, which is effective in blocking the activity of the enzyme Phospholipase A2, initiator of the phlogistic cascade and reducing the content of prostaglandins and other molecules endowed with pro-inflammatory, edemigenic, vasodilatory and platelet aggregating activity.

All this takes the form of effective control of the local inflammatory and allergic symptoms.

Studies carried out and clinical efficacy

BETAMETASONE IN THE TREATMENT OF PSORIASIS

Clin Lab. 2013; 59 (3-4): 277-82.

Study demonstrating the efficacy of the Betamethasone - Calcipotriol association in improving the clinical conditions of psoriasis patients. In addition to clinical evidence, the significant reduction in some disease markers such as beta defensins is of particular importance.

NEW BETAMETASONE DELIVERY SYSTEMS

J Drug Target. 2013 Jul; 21 (6): 542-50. doi: 10.3109 / 1061186X.2013.769106. Epub 2013 Feb 8.

Interesting work that experiments the usefulness of nanoparticles such as those of lecithin / chitosan in effectively conveying drugs such as Betamethasone.

CALCIPOTRIOLO / BETAMETASONE IN THE TREATMENT OF VITILIGINE

J Drugs Dermatol. 2012 Oct; 11 (10): e52-4.

Yet another study that reports the effectiveness of the associated treatment of Calcipotriol / Betamethasone in patients with vitiligo, significantly improving both the clinical course of the disease and the quality of life of the affected patient.

Method of use and dosage

BEBEN ®

Cream for topical use, cutaneous emulsion and 0.1% Betamethasone 17-benzoate gel.

The competent doctor should choose the pharmaceutical format and the suitable dosing schedule, based on the nature of the lesions and the severity of the clinical picture.

Generally, it is recommended to apply the appropriate amount of medicine directly to the affected region once a day.

Warnings BEBEN ® Betamethasone

Before starting BEBEN ® treatment it is necessary to consult your doctor with whom to evaluate the prescriptive appropriateness and the possible presence of contraindications to the use of corticosteroids by systemic route.

The patient should also pay attention to compliance with some useful rules to limit the incidence of potential side effects and to optimize therapeutic efficacy, such as avoiding applying the product to particularly large and compromised skin regions or thoroughly cleanse the hands after every application.

It is also useful to remember that the prolonged use of these drugs could induce the appearance of clinically relevant adverse reactions.

PREGNANCY AND BREASTFEEDING

The absence of clinical data able to better characterize the safety profile of Betamethasone for topical use for the health of the fetus and of the suckling and known the side effects derived from the systemic use of this drug, impose the extension of the aforementioned contraindications to the use of BEBEN ® also to pregnancy and the subsequent period of breastfeeding.

Interactions

The low systemic absorption of the active principle significantly limits the risk of clinically relevant drug interactions.

Contraindications BEBEN ® Betamethasone

The use of BEBEN ® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients and in patients suffering from serious bacterial and viral infections such as tuberculous, luetic and viral processes, rosacea or perioral dermatitis.

Undesirable effects - Side effects

Treatment with systemic corticosteroids with BEBEN ® exposes the patient to the risk of potential side effects such as itching, redness, irritation, dry skin, folliculitis, hypetricosis, acneiform eruptions, cutaneous hypopigmentation and atrophy.