SKINOREN ® Azelaic acid

SKINOREN ® is a drug based on Azelaic Acid

THERAPEUTIC GROUP: Anti-acne preparations for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications SKINOREN ® Azelaic acid

SKINOREN ® is indicated in the treatment of acne vulgaris in all its manifestations.

Mechanism of action SKINOREN ® Azelaic acid

Azelaic acid, active ingredient of SKINOREN ®, is a dicarboxylic acid extracted naturally from yeast, endowed with numerous biological activities not yet fully characterized.

However, the effectiveness in treating acne seems to correlate mainly with the antioxidant activity, which is important in countering the formation of free oxygen radicals responsible for oxidative damage, to the natural anti-inflammatory activity, to the antibacterial action directed against microorganisms such as Proprionibacterium acnes and keratolytic and comedolytic activity, important in normalizing the stratum corneum ensuring a prompt regression of the symptomatology in progress.

All the aforementioned activities are supported by the good pharmacokinetic properties that minimize the systemic absorption of the drug applied topically, limiting the occurrence of systemic side effects.

Studies carried out and clinical efficacy

AZELAIC ACID AND ACNEIC INFLAMMATORY LESIONS

J Drugs Dermatol. 2011 Jun; 10 (6): 586-90.

Work that demonstrates how Azelaic acid treatment can significantly improve the clinical conditions of patients suffering from hyperpigmented acne inflammatory lesions, reducing their severity in a few weeks of treatment.

ANTI-INFLAMMATORY ACTIVITY OF THE AZELAIC ACID

Exp Dermatol. 2010 Sep; 19 (9): 813-20. doi: 10.1111 / j.1600-0625.2010.01107.x. Epub 2010 Jul 2.

Molecular study demonstrating the anti-inflammatory potential of Azelaic acid, emphasizing its ability to modulate gene expression by reprogramming cellular activity and limiting the expression of pro-inflammatory mediators.

AZELAIC ACID, ACNE AND ANTIBIOTIC RESISTANCE

J Dtsch Dermatol Ges. 2010 Mar; 8 Suppl 1: S24-30. doi: 10.1111 / j.1610-0387.2009.07169.x.

Work that demonstrates the effectiveness of Azelaic acid in treating acne, emphasizing how this can prevent the onset of antibiotic resistance, which usually follows prolonged use of antibiotics.

Method of use and dosage

SKINOREN ®

Topical 20% Azelaic Acid gel.

The definition of the therapeutic scheme envisaged for the use of SKINOREN ® must necessarily be defined by the physician based on the clinical characteristics of the patient.

In principle it is advisable to apply the appropriate amount of cream directly on the region affected by the inflammatory process twice a day, preferably morning and evening.

Warnings SKINOREN ® Azelaic acid

The use of SKINOREN ® must be preceded by a careful medical examination in order to clarify the nature of the lesions and the prescriptive appropriateness of the drug.

The patient on SKINOREN ® therapy should pay attention to the application of some useful rules to safeguard the safety of the treatment such as cleaning the skin region to be treated before the application of the drug, avoiding contact with eyes and mucous membranes, avoiding exposure of the region treated with ultraviolet rays and wash your hands thoroughly after each application.

Keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

The aforementioned contraindications to the use of SKINOREN ® inevitably extend also to pregnancy and the subsequent period of breastfeeding, given the absence of studies able to characterize the safety profile of Azelaic acid for the health of the fetus and infant .

Interactions

The patient receiving SKINOREN ® should avoid topical application of other drugs.

Contraindications SKINOREN ® Azelaic acid

The use of SKINOREN ® is contraindicated in patients who are hypersensitive to the active substance or to one of its excipients.

Undesirable effects - Side effects

Therapy with SKINOREN ® could expose the patient to the risk of local and transient side effects such as burning, itching, scaling, pain and discoloration.

In the aforementioned cases it would be advisable to consult your doctor and possibly consider the possibility of suspending treatment until symptoms are regressed.

Clinically relevant adverse reactions are definitely rarer.