Vitamin B1 Angelini Urto ® - Thiamine

VITAMIN B1 ANGELINI URTO ® is a thiamine-based drug

THERAPEUTIC GROUP: Vitamin B1: thiamine

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Directions Vitamin B1 Angelini Urto ® - Thiamine

VITAMIN B1 ANGELINI URTO ® is indicated for the preferential treatment of vitamin B1 deficiency neuritis.

Mode of action Vitamin B1 Angelini Urto ® - Thiamine

VITAMIN B1 ANGELINI URTO ® is a thiamine-based drug, a key vitamin in balancing the energetic and biosynthetic state of the human body.

Concentrated in tissues such as cardiac and nervous, predominantly in the form of thiamine pyrophosphate, it acts as a cofactor of decarboxylases and transketolases, involved respectively in the generation of energy from various macromolecules and in the synthesis of nucleic acids.

The lack of this vitamin, fortunately rare and present above all in some risk categories such as alcoholics, manifests itself with an intense neuropathy characterized by intense pain in the limbs, convulsions and in the most serious cases with encephalopathy ..

In these conditions the intake of thiamine by parenteral route can determine a rapid regression of the symptoms, significantly improving the patient's health conditions.

Studies carried out and clinical efficacy

1. EARLY VITAMIN B1 DEFICIT IN DEVELOPING COUNTRIES

Important study aimed at raising the awareness of doctors operating in developing countries, regarding the presence of thiamine deficiency, also responsible for ataxia in pediatric patients.

2. FOOD HABITS AND DEFICIENCY OF VITAMIA B6

Very interesting study that investigates the possible effects of some unhealthy eating habits, such as the excessive consumption of isotonic drinks, able to reduce blood concentrations of thiamine, thus facilitating the appearance of serious side effects.

3. LACTIC ACIDOSIS AND VITAMIN B1 DEFICIT

Work that combines the lactic acidosis found in severely malnourished patients, the marked deficiency of thiamine pyrophosphate, and therefore the inability to effectively use the common aerobic glycolytic pathways.

Method of use and dosage

VITAMIN B1 ANGELINI URTO ®

Solution for injection for intramuscular use from 100mg of thiamine hydrochloride per ml of solution:

the treatment of thiamine deficiency syndromes, so serious as to cause the appearance of neuropathy, involves the administration by intramuscular use of 100 mg of thiamine every day or every other day, depending on the therapeutic needs.

In any case medical supervision is required.

Warnings Vitamin B1 Angelini Urto ® - Thiamine

Before injecting the medicine, it would be advisable to check the chemical and physical characteristics of the product, avoiding its intake in the presence of insoluble residues or showy opalescence.

Alcohol abuse is often associated with thiamine deficiency states sustained both by reduced dietary intake and impaired intestinal capacity.

PREGNANCY AND BREASTFEEDING

Given the absence of clinical trials and given the expected pharmaceutical form of this medicine, it is not recommended to use VITAMIN B1 ANGELINI URTO ® during pregnancy and possibly also in the subsequent breastfeeding period.

Interactions

The pharmacokinetic characteristics and half-life of thiamine could undergo significant changes following the simultaneous intake of furosemide and anticonvulsants.

Furthermore the intake of 5 florouracil, preventing the synthesis of thiamine pyrophosphate, could reduce the biological activity of this vitamin.

Contraindications Vitamin B1 Angelini Urto ® - Thiamine

The intake of VITAMIN B1 ANGELINI URTO ® is contraindicated in case of hypersensitivity to the active ingredient or to one of its excipients.

Undesirable effects - Side effects

Intramuscular injection of thiamine has been associated in rare cases with the onset of allergic reactions characterized by intense itching especially at the injection site, angioedema, urticaria, tachycardia, respiratory difficulties and in more serious cases anaphylactic shock.