LAMISIL ® Terbinafina

LAMISIL ® is a drug based on Terbinafine hydrochloride

THERAPEUTIC GROUP: Antimycotics for topical use - allylamines

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications LAMISIL ® Terbinafine

LAMISIL ® is indicated in the treatment of superficial skin infections and related appendages supported by dermatophytes, yeasts and fungi sensitive to Terbinafine.

Mechanism of action LAMISIL ® Terbinafine

LAMISIL ®, a drug based on Terbinafine, the active ingredient usually used orally, is a medicinal specialty useful during superficial fungal infections of the skin and skin appendages supported by dermatophytes, yeasts and fungi.

Permeated the cellular membranes of these pathogenic species, Terbinafine is able to inhibit the enzyme squalene-epoxidase, thus reducing the production of ergosterol, a key element of the cellular structure, and at the same time favoring the accumulation of intermediate metabolites able to interfere with normal cellular activities.

All this takes the form of a fungistatic and sometimes fungicidal action that guarantees immediate control of the symptoms.

Topical use of the product is also able to minimize the side effects of systemic therapy.

Studies carried out and clinical efficacy

NEW RELEASE SYSTEMS OF THE TERBINAFINE FOR THE TREATMENT OF CYNTHICOSIS

Eur J Pharm Sci. 2013 Jan 4; 48 (4-5): 628-636.

Interesting study that tests new release systems for Terbinafine useful in the treatment of onychomycosis, showing in some cases the excellent efficacy of action.

REASONS FROM IPERSENSIBILITY TO THE TERBINAFINE

Dermatol Online J. 2012 Nov 15; 18 (11): 5.

Case reports that demonstrate the appearance of adverse reactions to Terbinafine taken orally, in some cases so severe as to cause dermatological reactions such as epidermal necrolysis.

TERBINAFINE AND CRIPTOCOCCO

Mem Inst Oswaldo Cruz. 2012 Aug; 107 (5): 582-90.

A study that demonstrates how Terbinafine, even in monotherapy, can guarantee an inhibition of Cryptococcus growth, also modulating the morphology of its colonies and thus compromising its invasive and pathogenic capacities.

Method of use and dosage

LAMISIL ®

Cream for cutaneous use with 1% Terbinafine hydrochloride;

1% skin solution of Terbinafine hydrochloride;

1% Terbinafine hydrochloride skin spray.

Generally the application of LAMISIL ® to the skin region affected by the infectious process once or twice a day is sufficient to guarantee a regression of the symptoms.

Despite this, both the duration and the treatment scheme should be defined by the physician based on the physio-pathological characteristics of the patient and his / her clinical picture.

Warnings LAMISIL ® Terbinafina

Before using LAMISIL ® for topical use, careful cleaning of the treated area is recommended.

The same precaution must be maintained in the phases following the treatment, taking care to cleanse the hands thoroughly, in order to avoid possible contact with the mucous membranes.

Given the photosensitizing power of Terbinafine, it is recommended to avoid direct exposure to sunlight.

Keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

Given the limited clinical experience available and the absence of clinical trials able to clarify the safety profile of Terbinafine for fetal health, it would be appropriate to extend the aforementioned contraindications also to pregnancy and the subsequent breastfeeding period.

Interactions

The low systemic absorption of Terbinafine taken topically minimizes the risk of clinically relevant drug interactions.

Contraindications LAMISIL ® Terbinafine

LAMISIL ® is contraindicated in patients who are hypersensitive to the active substance or to one of its components and to pediatric patients.

Undesirable effects - Side effects

The side effects observed following the topical use of LAMISIL ® are generally local and transient, characterized by redness, itching, discomfort and in the most serious cases hypersensitivity reactions.