CITROSIL ® Benzalkonium chloride

CITROSIL ® is a drug based on Benzalkonium chloride

THERAPEUTIC GROUP: Antiseptics and disinfectants

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications CITROSIL ® Benzalkonium chloride

CITROSIL ® is indicated for cleaning and disinfection of intact and damaged skin.

Mechanism of action CITROSIL ® Benzalkonium chloride

CITROSIL ® is a drug based on Benzalkonium chloride, a quaternary ammonium derivative whose structure must inevitably also have therapeutic properties.

In fact, as an anionic detergent it is able to quickly bind negatively charged surfaces, such as bacterial membranes, interposing itself with the membrane itself and altering its normal structure.

The formation of pores and the altered permeability of the membrane thus determines the loss of enzymes, coenzymes and ions, seriously compromising the biosynthetic properties of the cell until it determines its death.

The wide spectrum of action of Benzalkonium chloride, effective both against Gram positive bacteria and Gram negative bacteria and some fungi, does not extend however to spores and Micobacterium tuberculosis, still allowing an excellent cleansing and disinfection of intact skin and injured skin.

Studies carried out and clinical efficacy

DISINFECTION WITH BENZALCONIUM CHLORIDE AND ULTRASIONS

Lett Appl Microbiol. 2013 May 18.

Combined effect of benzalkonium chloride and ultrasound against Listeria monocytogenes biofilm on plastic surface.

Torlak E, Sert D.

Interesting work that evaluates the possible use of Benzalkonium chloride in combination with ultrasound for the disinfection of plastic objects for surgery from Listeria Monocytogenes, a pathogenic species generally resistant to common disinfectants

MECHANISMS OF RESISTANCE TO BENZALCONIUM CHLORIDE

J Proteomics. 2013 May 4.

Molecular study that tries to best characterize the molecular properties at the basis of the onset of Benzalkonium chloride resistance mechanisms in Pseudomonas aueriginosa.

Such data could be important to limit the spread of resistant microbial strains.

NEW RELEASE METHODS FOR BENZALCONIUM CHLORIDE

Biofouling. 2013; 29 (3): 261-71.

Interesting work that evaluates new pharmacokinetic approaches oriented to the gradual release of benzalkonium chloride, in such a way as to prolong the disinfecting effect as much as possible.

Method of use and dosage

CITROSIL ®

Cutaneous solution and cutaneous spray of 175 mg of Benzalkonium chloride per 100 ml of product.

The correct use of CITROSIL ® requires the application of the product twice a day on the skin region to be treated.

If the skin was intact it would be advisable to rub with the gauze soaked in the affected region, instead making the compresses with sterile gauze soaked in the drug in the case of injured skin.

Warnings CITROSIL ® Benzalkonium chloride

The use of CITROSIL ®, although it is safe and free from clinically relevant side effects, should be carried out with particular care, taking care to avoid contact of the drug with the eye or mucous membranes.

Treatment with CITROSIL ® should generally be of short duration, immediately suspending its use in the event of local adverse reactions.

It is also recommended to avoid exposure to sunlight from the treated skin region, given the photosensitising power of Benzalkonium chloride.

Keep the medicine out of the reach of children

PREGNANCY AND BREASTFEEDING

The absence of systemic absorption of the active ingredient of CITROSIL ® allows the use, justified and superivisioned by your doctor, of CITROSIL ® during pregnancy and in the subsequent period of breastfeeding.