Generality Sotos syndrome is a rare genetic disorder characterized by excessive skeletal growth, craniofacial anomalies, mental retardation, motor problems and behavioral problems. Due to the mutation of the NSD1 gene, Sotos syndrome is a condition acquired during embryonic development, in more than 90% of cases, and a hereditary condition, in the percentage of remaining cases; therefore, it is almost always the result of a new mutational event
