ROSICED ® Metronidazole

ROSICED ® is a Metronidazole-based drug

THERAPEUTIC GROUP: Chemotherapy for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications ROSICED ® Metronidazole

ROSICED ® is indicated for the topical treatment of papulopustular inflammatory manifestations of rosacea.

Mechanism of action ROSICED ® Metronidazole

ROSICED ® is a drug based on metronidazole, used in the treatment of rosacea, characterized by papulo-pustular lesions with an inflammatory course.

Topically applied, metronidazole is selectively absorbed by anaerobic and protozoan bacteria, permeating the plasma membrane and reaching the cytosolic environment, in which interacting with thiol groups of various enzymes determines the block of its functionality.

But the bactericidal action of metronidazole is certainly due to the ability of its intracellular catabolites to interact with bacterial DNA, forming unstable intermediates that seriously compromise the vitality of the microorganism.

This action is carried out exclusively in anaerobic bacteria, given the presence of a micro-environment particularly suited to the various chemical transformations of metronidazole, necessary for obtaining an active and effective catabolite.

Studies carried out and clinical efficacy

TOPIC TREATMENT OF ROSACEA

Hautarzt. 2013 Jul; 64 (7): 494-9. doi: 10.1007 / s00105-012-2518-5.

Interesting review that re-evaluates the effectiveness of the various therapies for rosacea in the light of the most recent clinical evidence. Topical treatment with metronidazole certainly remains a cornerstone of the correct therapeutic approach, especially in the maintenance phases.

EFFECTIVENESS OF METRONIDAZOLE IN THE TREATMENT OF ACNE VOLGARE

Indian J Dermatol. 2012 Jul; 57 (4): 279-81. doi: 10.4103 / 0019-5154.97666.

A clinical trial that demonstrates how Metronidazole 2% gel can be effective and very well tolerated in the treatment of mild acne of moderate intensity.

METRONIDAZOLE IN GINGIVITIS MANAGEMENT

J Int Acad Periodontol. 2012 Oct; 14 (4): 91-6.

A curious study that demonstrates the efficacy of Metronidazole in combination with Chlorhexidine in ensuring a correct management of gingivitis, reducing plaque production, often associated with the aforementioned pathology.

Method of use and dosage

ROSICED ®

Metronidazole 7.5 mg cream per gr of product.

Generally it is recommended to apply the appropriate amount of cream directly on the lesions of the face, twice a day for at least 6 weeks.

Evidently the precise definition of the therapeutic scheme is up to his physician based also on the clinical characteristics of the pathology and on the severity of the complained symptomatology.

Warnings ROSICED ® Metronidazole

The patient on ROSICED ® therapy should pay particular attention to compliance with specific sanitary regulations useful for limiting the incidence of potential side effects and at the same time optimizing the therapeutic efficacy.

In particular it should:

avoid contact of the drug with eyes and mucous membranes;
clean hands thoroughly after each application;
keep the medicine out of the reach of children;
avoid exposure of the treated region to ultraviolet radiation;
consult a doctor immediately following the occurrence of unwanted adverse reactions.

PREGNANCY AND BREASTFEEDING

The absence of clinical trials able to better characterize the safety profile of Metronidazole for fetal and infant health, the presence of contradictory data related to the teratogenicity of this active ingredient taken in the first trimester generally extend the contraindications to the use of ROSICED ® also to the pregnancy, in particular to the first trimester, and to the following period of breastfeeding.

Interactions

The topical use of Metronidazole, and therefore the very low systemic absorption, significantly reduce the risk of clinically relevant drug interactions.

Contraindications ROSICED ® Metronidazole

The use of ROSICED ® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients, in patients with severe hepatic, hematologic and neurological diseases and in women who are pregnant at the first trimester.

Undesirable effects - Side effects

ROSICED ® is generally well tolerated although it is quite common to have adverse local and transient reactions such as contact dermatitis, erythema, dry skin and rash.