EPIDUO ® Benzoyl peroxide + Adapalene

EPIDUO® is a drug based on Benzoyl Peroxide + Adapalene

THERAPEUTIC GROUP: Anti-acne preparations for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications EPIDUO ® Benzoyl peroxide + Adapalene

EPIDUO® is indicated in the treatment of Acne vulgaris characterized by comedones, papules and pustules both inflamed and not inflamed.

Mechanism of action EPIDUO ® Benzoyl peroxide + Adapalene

EPIDUO® is a drug that combines two active antiacne ingredients generally used as monotherapy whose association, however, is clinically effective and pharmacologically safe.

More precisely, the Adapalene, as a synthetic retinoid is able, once applied topically, to interact with specific cellular receptors, reprogramming the gene expression and favoring a normalization of the stratum corneum thus avoiding the formation of microcomedones, the perfect medium of growth of Proprionibacterium acnes.

The activity of Adapalene is associated with the antiseptic and bacteriostatic activity of benzoyl peroxide, capable of limiting bacterial proliferation, thus reducing the inflammatory stimulus caused by these bacteria and responsible for the inflammatory evolution of the lesion.

Both active ingredients also perform a modest exfoliating and sebostatic action, useful for restoring the correct skin and epidermal balance.

Studies carried out and clinical efficacy

SEBOSTATIC ACTION OF ADAPALENE

J Dermatol Sci. 2013 Jun; 70 (3): 204-10. doi: 10.1016 / j.jdermsci.2013.02.003. Epub 2013 Feb 14.

Work that shows how Adapalene can inhibit sebum accumulation by suppressing triglyceride production and reducing cell differentiation in sebaceous cells.

Everything seems to be accomplished through the control of gene expression.

ADAPALENE / BENZOYL PEROXIDE AND QUALITY OF LIFE OF THE PATIENT WITH ACNE

J Drugs Dermatol. 2012 Jun; 11 (6): 714-22.

Study demonstrating that the association between Benzoyl Peroxide and Adapalene can significantly improve the quality of life of the patient suffering from Acne vulgaris, reducing the phlogistic extent of skin lesions.

ANTIBIOTIC THERAPY + TOPIC THERAPY IN THE TREATMENT OF ACNE

J Dermatol. 2012 Jun; 39 (6): 511-5. doi: 10.1111 / j.1346-8138.2011.01450.x. Epub 2011 Dec 14.

Clinical trial demonstrating that topical Adapalene combination therapy and oral antibiotic therapy can significantly improve the clinical condition of patients with medium and severe acne in just a few weeks of treatment.

Method of use and dosage

EPIDUO®

Topical gel with 0.1% Adapalene and 2.5% Benzoyl peroxide.

The correct use of EPIDUO® involves applying the correct amount of gel to the skin region to be treated, preferably in the evening and after thoroughly cleansing the face.

The duration or possible corrections of the standard therapy should be defined by the competent doctor.

Warnings EPIDUO ® Benzoyl peroxide + Adapalene

EPIDUO® therapy should be preceded by a careful medical examination in order to clarify the origin of the lesion and therefore the prescriptive appropriateness of the drug.

In order to optimize the effectiveness of the therapy by reducing the side effects, it would be appropriate for the patient to pay attention to compliance with some important rules such as:

thoroughly clean the area to be treated before applying the gel;
clean hands after using the medicine;
avoid ingestion and contact of the drug with eyes and mucous membranes;
avoid the use of the medicine in case of contextual dermatological pathologies;
avoid exposure of the treated area to sunlight.

It is also recommended to keep the medicine in a cool and dry place, out of reach of children.

PREGNANCY AND BREASTFEEDING

Note the side effects of retinoids taken orally by the fetus and the clinical characteristics of their topical use during pregnancy and the subsequent breastfeeding period are unknown, it would be appropriate to extend the aforementioned contraindications to the use of EPIDUO® also to the expectant mother and the nurse.

Interactions

The patient receiving EPIDUO® should avoid the simultaneous intake of oral corticosteroids and any other topical medicine, in particular those with exfoliating and keratolytic properties.

Contraindications EPIDUO ® Benzoyl peroxide + Adapalene

The use of EPIDUO® is contraindicated in patients hypersensitive to the active ingredient or to one of its excipients and in patients suffering from dermatological diseases.

Undesirable effects - Side effects

EPIDUO® therapy, especially when prolonged over time, could lead to the appearance of local adverse reactions such as redness, burning, pain, erythema and itching fortunately without any particular clinical complications.

The associated adverse reactions sustained by hypersensitivity to the drug are decidedly more rare.