Lintos ® Ambroxol

LINTOS ® is a drug based on Ambroxol hydrochloride

THERAPEUTIC GROUP: Mucolytics

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications Lintos ® Ambroxol

LINTOS ® is used in the symptomatic treatment of respiratory tract diseases characterized by hypersecretion of thick and viscous mucus.

Mechanism of action Lintos ® Ambroxol

LINTOS ® is a medicinal specialty, used in the therapeutic field as a mucolytic, based on Ambroxol, an active ingredient chemically obtained from Bromexine and endowed with numerous biological activities that make it today one of the most used molecules in the clinical field.

Taken orally this active principle is rapidly absorbed by the gastro-enteric mucosa, reaching the pulmonary environment after a few tens of minutes, the main site of its therapeutic activity, and carrying out this function for over 7 hours, after which, after a metabolism hepatic, is eliminated via the kidneys.

In light of recent scientific evidence, the clinical efficacy of Ambroxol is essentially to be attributed to:

to the antioxidant activity, useful in protecting the respiratory mucosa from the oxidative insult exerted by the reactive oxygen species;
to the anti-inflammatory activity, exercised through the control of the secretion of inflammatory cytokines responsible for the recruitment of elements of inflammation in the center;
to the action inducing the production of surfactant, useful in improving lung activity;
the ability to optimize the chemical composition of the mucus, improving its fluidity;
the ability to induce an improvement in the mucociliary activity of the upper respiratory tract.

Studies carried out and clinical efficacy

CLINICAL EFFECTIVENESS OF AMBROXOL

Intern Med. 2002 Dec; 41 (12): 1175-8.

An interesting clinical case that demonstrates how the treatment with Ambroxol at 45 mg daily, was decisive for a patient of 79 years with strong dyspnea and marked hypereosinophilia, such as to determine the formation of a hyperdense mucus.

ANTI-INFLAMMATORY ACTION OF AMBROXOL

Intensive Care Med. 2004 Jan; 30 (1): 133-40. Epub 2003 Sep 20.

Experimental study that emphasizes the impressive anti-inflammatory capacity of Ambroxol demonstrating the ability of this active ingredient in reducing the secretion of inflammatory cytokines during lipopolisaccaride-mediated infection.

ANTIOXIDANT ACTION OF AMBROXOL

Clin Exp Med. 2004 Dec; 4 (3): 152-8.

An interesting study conducted both in vivo and in vitro, which demonstrates how treatment with Ambroxol can significantly reduce the cytological and histological damage caused by reactive oxygen species on the gastric mucosa.

Method of use and dosage

LINTOS ®

Ambroxol 30 mg syrup per 10 ml of product.

Stressing that the decision of the dosage and the timing of the assumption is up to the doctor, after having carefully evaluated the patient's state of health, in principle the intake of 10 ml of syrup a day for 3 times a day for a few days, would result effective in adult patients to ensure a rapid improvement in the complained symptomatology.

Warnings Lintos ® Ambroxol

Although the use of LINTOS ® is generally well tolerated and has no clinically relevant side effects, the patient should consult his doctor before taking this medicine.

Pathological conditions such as severe hepatic and renal diseases, peptic ulcers rather than difficulty in breathing and expectoration, could compromise the safety of therapy with Ambroxol, sometimes defining serious pictures of bronchopulmonary obstruction.

LINTOS ® contains:

sorbitol, therefore being little indicated in patients with fructose intolerance;
glycerol, responsible for headache, nausea, vomiting and diarrhea;
benzoic acid, potentially responsible for jaundice in newborns.

PREGNANCY AND BREASTFEEDING

The ability of Ambroxol to cross the placental barrier and the breast filter, exposing itself in relevant concentrations to both the fetus and the infant, extend the aforementioned contraindications to the use of LINTOS ® also to pregnancy and the subsequent period of breastfeeding.

Interactions

Ambroxol could increase the concentrations of certain antibiotics in bronchopulmonary secretions and saliva, without compromising their clinical effectiveness.

Contraindications Lintos ® Ambroxol

The use of LINTOS ® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients, in patients with gastro-duodenal ulcer, in patients suffering from severe liver and kidney diseases and in small patients under the age of 2 years.