MICLAST ® - Ciclopirox

MICLAST ® is a drug based on Ciclopirox

THERAPEUTIC GROUP: Antimycotics for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications MICLAST ® - Ciclopirox

MICLAST ® is indicated in the treatment of cutaneous mycoses sustained by fungi sensitive to Ciclipirox.

Mechanism of action MICLAST ® - Ciclopirox

Ciclopirox, active ingredient of MICLAST ®, is a molecule with fungistatic, fungicidal and bacteriostatic activity and therefore successfully used in the treatment of dermatomycoses.

The mechanism of action of Ciclopirox, responsible for the aforementioned therapeutic activities, is determined by the chelating activity typical of this molecule, effective in removing important ions from the bacterial metabolism, such as iron, thus compromising the metabolic capacities and vitality of the cell.

Despite the aforementioned well-characterized mechanism of action, Ciclopirox is also attributed to other biological activities such as anti-inflammatory ones, important in significantly limiting the inflammatory symptomatology that is often associated with cutaneous mycoses

Studies carried out and clinical efficacy

OTTOSSICITA 'DEL CICLOPIROX

Otol Neurotol. 2008 Oct; 29 (7): 910-3. doi: 10.1097 / MAO.0b013e318184f4a9.

Experimental study that tests the ototoxic potential of Ciclopirox, defining a good tolerability that is important for the clinical extensions of the medicine to ear diseases such as otomycosis.

CYCLOPIROX IN THE TREATMENT OF SEBORROCIC DERMATITIS

Skin Therapy Lett. 2004 Jun-Jul; 9 (6): 4-5.

Clinical trial demonstrating the clinical efficacy of Ciclopirox in the treatment of inflammatory diseases such as seborrheic dermatitis even when complicated by bacterial superinfections.

CLINICAL PROPERTIES OF CICLOPIROX

Int J Dermatol. 2004 Jul; 43 Suppl 1: 3-8.

Work that demonstrates the therapeutic efficacy of Ciclopirox, highlighting a significant broad-spectrum anti-fungal, antibacterial and anti-inflammatory activity useful to guarantee a rapid remission of symptoms.

Method of use and dosage

MICLAST ®

1% cutaneous solution of Ciclopirox olamina;

Cream for cutaneous use at 1% of Ciclopirox olamina;

1% cutaneous emulsion of Ciclopirox olamina;

1% cutaneous powder of Ciclopirox olamina.

The therapeutic scheme as well as the choice of the pharmaceutical format is the responsibility of the competent doctor in the treatment of cutaneous mycoses.

Generally we recommend the use of MICLAST ® in cream for the treatment of glabrous surfaces and limited extension, MICLAST ® in skin emulsion for the treatment of mycosis of the areas provided with hair, MICLAST ® in skin powder for the treatment of foot infections and MICLAST ® in a cutaneous solution for the treatment of large skin lesions.

Warnings MICLAST ® - Ciclopirox

MICLAST ® therapy should be defined and supervised by a physician experienced in the treatment of dermatomycoses, who should provide the patient with all the information necessary to limit the occurrence of side effects and to optimize the effectiveness of the therapy.

Ciclopirox should be used with particular caution in patients undergoing immunosuppressive therapy, in patients with HIV or other immune system disorders and in diabetic subjects.

The use of MICLAST ®, due to some excipients such as benzoic acid or stearyl alcohol, could determine the onset of local adverse reactions of a transitory nature.

It is advisable to keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

The use of MICLAST ® during pregnancy and in the subsequent period of breastfeeding should be limited to cases of real need and always under the strict supervision of your doctor.

Interactions

Drug interactions worthy of clinical note are currently unknown.

Contraindications MICLAST ® - Ciclopirox

The use of MICLAST ® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients.

Undesirable effects - Side effects

The use of MICLAST ®, especially when prolonged over time, could determine the appearance of local adverse reactions such as redness, burning and erythema.

Fortunately, clinically relevant side effects are rarer