Symptoms Diabetes insipidus

Related articles: Diabetes insipid


Rare metabolic disease caused by reduced secretion of the pituitary hormone vasopressin (which acts at the kidney level stimulating the reabsorption of water and opposing diuresis) or a reduced sensitivity of these organs to its action. Consequently, the key symptom of diabetes insipidus is the production of large amounts of diluted urine associated with intense thirst. The adjective insipid differentiates it from the most common form of diabetes, the mellitus one, caused by a reduced secretion and / or action of insulin, in which the urine appears as sweet as honey (from which mellitus) due to the presence of glucose. There is no kind of correlation between the two forms.

Most common symptoms and signs *

  • Bladder dysfunction
  • Dehydration
  • hypohidrosis
  • Hypovolemia
  • nocturia
  • Polyhydramnios
  • Polyuria
  • Thirst
  • Intense thirst

Further indications

Under normal conditions a healthy adult produces 1.5 to 2.5 liters of urine per day; in the presence of diabetes insipidus these volumes can vary from 3 to 15 liters / day in the most serious cases.