DOVOBET ® is a drug based on Calcipotriol + Betamethasone
THERAPEUTIC GROUP: Antipsoriatics for topical use
IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects
Indications DOVOBET ® Calcipotriol + Betamethasone
DOVOBET ® is indicated in the treatment of psoriasis of the scalp in adults and of mild to moderate plaque psoriasis common also in other areas of the body.
Mechanism of action DOVOBET ® Calcipotriol + Betamethasone
Calcipotriol and Betamethasone, active ingredients of DOVOBET ®, are drugs with different biological activities but both useful in the management and treatment of psoriasis.
In fact, while Betamethasone, a synthetic corticosteroid, is able to control the phlogistic evolution of the disease, reducing the production of inflammatory mediators and the recall of cellular elements with inflammatory power, the Calcipotriol, a synthetic analogue of vitamin D3, is able to permeate the cellular membranes of keratinocytes, reprogramming the gene expression and thus determining a block of the proliferative processes, mediated also by the induction of the apoptotic event, and a resumption of the differentiation process.
The combination of these two active ingredients has proved particularly effective in the treatment of psoriasis, significantly improving the quality of life of affected patients, and generally safe given the low systemic absorption resulting from the topical use of the medicine.
Studies carried out and clinical efficacy
CLOVICAL EFFECTIVENESS OF DOVOBET
J Dermatolog Treat. 2007; 18 (6): 361-5.
Study that tests the effectiveness of two drugs widely used in the treatment of psoriasis, including DOVOBET ®, demonstrating the greatest efficacy of the latter, even with shorter treatment times, given the association of Calcipotriol with Betamethasone.
SATISFACTION OF PATIENTS IN TREATMENT WITH DOVOBET
Eur J Dermatol. 2009 Nov-Dec; 19 (6): 581-5. doi: 10.1684 / ejd.2009.0767. Epub 2009 Sep 2.
Interesting work that tests the satisfaction of psoriasis patients for treatment with DOVOBET, registering a consensus in over 80% of patients that they can contribute to the co-payment of the drug in association with the national health system.
EFFECTIVENESS OF DAILY SINGLE ADMINISTRATION
Am J Clin Dermatol. 2011 Dec 1; 12 (6): 421-4. doi: 10.2165 / 11207670-000000000-00000.
Pharmacokinetic study that seeks to better characterize the efficacy of the various dosages in the treatment of psoriasis, thus identifying the most effective scheme for the treatment of psoriasis of the trunk of the limbs and scalp in the daily single-dose administration.
Method of use and dosage
DOVOBET ®
Topical gel with 50 mcg of Calcipotriol and 0.5 mg of Betamethasone per gram of product.
Generally it is recommended to apply the appropriate amount of gel directly on the areas affected by the pathology.
The duration of the therapy, which should in any case be defined by your doctor based on the patient's state of health and the severity of the relative clinical picture, should not exceed 4 weeks in the treatment of scalp psoriasis the 8 weeks for treatment of other locations.
Warnings DOVOBET ® Calcipotriol + Betamethasone
The patient receiving DOVOBET ®, in order to preserve the efficacy and safety of the drug, should pay particular attention to compliance with certain sanitary regulations, which the doctor should define before starting the treatment.
Thoroughly clean your hands after each application, avoid applying the drug on injured skin regions, avoid putting eyes, mouth and mucous membranes in contact with the drug, avoid exposure to solar radiation after application, request continuous medical supervision during treatment and consult your doctor following the appearance of unwanted effects, are the main precautions that every patient receiving DOVOBET ® should respect.
PREGNANCY AND BREASTFEEDING
The aforementioned contraindications to the use of DOVOBET ® should also be extended to pregnancy and the subsequent breastfeeding period, given the absence of studies able to better characterize the safety profile of the drug for fetal and infant health.
Interactions
The patient receiving DOVOBET ® should avoid applying other products topically in the same treated skin area, especially those based on corticosteroids.
Contraindications DOVOBET ® Calcipotriol + Betamethasone
The use of DOVOBET ® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients, in patients with altered calcium metabolism, in the forms of guttate, erythrodermic, exfoliative and pustular psoriasis, in patients suffering from severe hepatic impairment and renal and in patients with skin infections, skin atrophy, capillary fragility, acne, ulcers, wounds and perianal itching.
Undesirable effects - Side effects
Itching, redness, skin pain, erythema and burning are the main side effects, all of a local and transitory nature, reported by patients on DOVOBET ® therapy.
Fortunately, clinically relevant adverse reactions are rarer
Note
DOVOBET ® is a prescription-only drug.
