Drugs against omnicomosis

Definition

Onychomycosis is a disease of the nails - usually of the feet - generated by fungi or bacteria: these pathogens can trigger infection in one part of the nail, in the entire nail or even affect the others. Onychomycosis is more common among diabetics and the elderly.

Causes

The fungi - including Candida albicans, Trichophyton and Epidermophyton - are undoubtedly the main triggers for onychomycosis: however, even molds and yeasts (eg Aspergillus ) can cause or enhance damage.

Pests generate damage only under certain conditions; among the predisposing factors of the onychomycosis, we mention: weakening of the host's immune defenses, damp places, athlete's foot, psoriasis, lack of transpiration of the feet, high temperature associated with sweating and peripheral vasculopathies.

Symptoms

In the case of onychomycosis, the diseased nail undergoes an alteration of its natural color; moreover, it appears more fragile, friable, deformed and tends to thicken. The progression of onychomycosis could generate a bad odor, as well as infect the surrounding skin and then spread to other areas of the body. In case of severity, it is possible to lose the nail.

Natural Care

Information on onychomycosis - drugs for the treatment of omnicomosis are not intended to replace the direct relationship between health professional and patient. Always consult your doctor and / or specialist before taking Onychomycosis - Drugs for the treatment of omnicomosis.

drugs

The preferred pharmacological therapy for onychomycosis is performed with the application of antifungals with topical action and / or intake of systemic antifungals.

Among the TOPICAL ANTIMICOTICS (to be used only in the case of onychomycosis limited to one or two nails) we recall:

AZOLIC DERIVATIVES: ketoconazole (eg Ketoconazole EG), apply the drug in situ as a 2% cream, twice a day for two weeks. Another azole derivative is miconazole (eg Daktarin), particularly indicated for Candida onychomycosis: applying the cream twice a day to the affected surface leads to the resolution of the infection in two to three weeks. The dressing should be repeated until complete eradication of the fungus.
MORPHOLINE DERIVATIVES: amorolfine (eg Locetar): in the form of enamel, to be applied after thorough cleaning of the diseased nail once a week until the nail is healed. Lolfolfine exerts an excellent fungicidal and fungistatic action.
ALLILAMINE: naftifina (eg Suadian) is included in this pharmacological class, a substance indicated in the case of onychomycosis by dermatophytes; the substance is less active against yeasts. Available in 1% cream to be applied to the nail and surrounding area twice a day.
CICLOPIROX (eg Fungizione), enamel (8% solution): apply the product on the nail surface affected by onychomycosis once a day (preferably in the morning or eight hours before washing), using a special applicator. After 8 days, remove the product with alcohol. Repeat this treatment mode so that the nail will be healed.
POLYESIS: as we have analyzed for vulvovaginal candidiasis and thrush, polyenics are very effective against Candida infections, but ineffective against dermatophytes. Among the polyenics there are creams based on nystatin (eg. Assocort, Mycostatin), to be applied on the nail and on the surrounding skin 2-4 times a day, depending on the severity of the onychomycosis.
TOLNAHTATE: they represent a class of drugs able to act selectively against skin infections caused by Trichophyton and Epidermophyton . They are not active against onychomycosis due to Candida albicans. In the form of cream, solution or powder, the tolnaftates (eg Tinaderm) should be applied twice a day, on the affected lamina, until the problem is completely resolved.

Drugs with topical application against onychomycosis can cause discoloration, local edema, exfoliation of the skin, nail pain, periungual phlogosis, local dryness, skin rash. The manifestation of side effects and their intensity is different based on the sensitivity of the subject and the choice of a given drug rather than another.

In the case of severe onychomycosis, alongside the topical treatment, it is advisable to take some oral pharmacological substances, which act by acting from within and eliminating the responsible pathogen more effectively.

Among the DRUGS AGAINST IONOMYCOSIS AT SYSTEMIC ACTION, azole derivatives stand out once again: in particular, imidazoles and triazolics are the drugs of choice. Griseofulvin is also a particularly effective active against onychomycosis, but less used because it is ineffective against Candida albicans.

Imidazole (eg miconazole: Oravig): it acts by altering the membrane permeability of fungal cells. Take one tablet (50 mg) orally, once a day for 14 consecutive days.
Triazole (eg. Itraconazole: Sporanox): it is particularly effective against onychomycosis at a dose of 200 mg / day, for three consecutive months.

Not to be used in the event of ventricular dysfunction: prolonged use of itraconazole (per os) may cause heart failure.

Griseofulvin (eg Fulcin): micronized Griseofulvin is available in 500 mg tablets, to be taken once a day (single dose or multiple doses of 125 mg); for the treatment of relapses, it is possible to take up to 1 mg per day of active ingredient.

NB prevention is certainly the best cure against onychomycosis: