ROZEX ® is a Metronidazole based drug
THERAPEUTIC GROUP: Antiprotozoans - Chemotherapy for topical use
IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects
Directions ROZEX ® Metronidazole
ROZEX ® is indicated for topical use in the treatment of dermatological manifestations of an erythematous and papulo-pustular nature of rosacea.
Mechanism of action ROZEX ® Metronidazole
ROZEX ® is a drug particularly used in the clinical-dermatological field due to the ability to promptly guarantee a remission of the symptoms present in the course of rosacea, dermatoses of the face in which different pathogenic microorganisms could also be included.
More precisely, Metronidazole present in this drug, properly metabolized by pathogenic nitroradical microorganisms, is able to interact with bacterial DNA forming inactive complexes that block all processes of duplication and gene expression, thus reducing the proliferative and vital capacity of the microorganism .
From the pharmacokinetic point of view, on the other hand, topical application of ROZEX ® minimizes the systemic absorption of Metronidazole, thus minimizing the risk of drug interactions and clinically relevant side effects.
Studies carried out and clinical efficacy
METRONIDAZOLE IN THE TREATMENT OF ACNE
Indian J Dermatol. 2012 Jul; 57 (4): 279-81.
Study demonstrating the effectiveness of a 2% Metronidazole gel in treating medium-sized vulgar acne, revealing the ability to significantly improve inflammatory lesions and the clinical course of the disease.
NEW METRONIDAZOLE RELEASE SYSTEMS
Chem Pharm Bull (Tokyo). 2007 Aug; 55 (8): 1141-7.
Work that evaluates the different pharmacokinetic characteristics of various polymers that can be used as Metronidazole delivery systems able to improve the efficacy of the drug, allowing a gradual release of the same.
METRONIDAZOLE AND PROTECTIVE FACTOR IN THE TREATMENT OF ACNE ROSACEA
Skin Therapy Lett. 2001 May; 6 (8): 1-2.
Study demonstrating the efficacy of a Metronidazole-based and protective factor 15 cream in treating inflammatory, erythematous and telangiectasia lesions present during acne rosacea.
Method of use and dosage
ROZEX ®
Topical 0.75% Metronidazole Cream.
We recommend applying the correct amount of cream to the areas of the face affected by dermatosis twice a day, massaging them lightly.
Before using ROZEX ® it is advisable to thoroughly cleanse the area without causing obvious lesions.
In order for the benefits to be observed, it is advisable for the therapy to be prolonged for several weeks.
Warnings ROZEX ® Metronidazole
The use of ROZEX ® should be preceded by a careful medical examination in order to assess the prescriptive appropriateness and the possible presence of conditions incompatible with the therapy as hematological and neurological pathologies.
Given the photosensitizing power of Metronidazole, it would be advisable to avoid direct exposure to ultraviolet rays in order to reduce the incidence of possible burns.
PREGNANCY AND BREASTFEEDING
Although the topical use of Metronidazole significantly reduces the risk of direct exposure to the fetus of the drug, present instead for oral intake, it would be advisable to use ROZEX ® with caution and under medical supervision both during pregnancy and in the subsequent breastfeeding period. otherwise.
Interactions
The topical use of Metronidazole, limiting the systemic absorption of the drug, significantly contains the risk of clinically relevant drug interactions.
Nevertheless, the patient receiving ROZEX ® should avoid the simultaneous intake of alcohol due to the risk of disulfiram-like syndrome, characterized by vomiting, headache and cramped abdominal pain.
Contraindications ROZEX ® Metronidazole
The use of ROZEX ® is contraindicated in patients who are hypersensitive to Metronidazole or to any of its excipients contained in the drug.
Undesirable effects - Side effects
The application of ROZEX ® could determine with a certain frequency the comparison of local side effects such as dry skin, erythema, itching and skin discomfort.
The systemic effects such as nausea or sensory changes are very rare.
Note
ROZEX ® is a prescription-only drug.
