ACY ® Aciclovir

ACY ® is a drug based on Acyclovir

THERAPEUTIC GROUP: Chemotherapy for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications ACY ® Aciclovir

ACY ® is indicated for the treatment of Herpes Simplex skin infections.

Action mechanism ACY ® Aciclovir

ACY ® is a drug based on acyclovir, the active ingredient successfully used in the treatment of cutaneous infections caused by visus like Herpes Simplex type 1 and 2.

Its therapeutic activity is due to the ability of the active principle to easily permeate the membranes of infected cells, to be transformed into the active compound Aciclovir triphosphate by the viral thymidine kinase enzyme and thus inhibit the viral DNA polymerase.

The above biological mechanisms are concretized with the arrest of the viral replication and the consequent remission of the symptomatology in progress.

Topical use of this medicine, greatly limiting the systemic absorption of the drug, makes the therapy as safe and free from clinically relevant side effects.

Studies carried out and clinical efficacy

EFFECTIVENESS OF COMBINED THERAPY IN POSITIVE HIV PATIENTS

An Bras Dermatol. 2011 Sep-Oct; 86 (5): 1043-5.

Study demonstrating the need to combine aciclovir with other drugs such as Imiquimod to optimize the therapeutic response to particular cases of relapsing Herpes simplex such as that affecting HIV positive patients.

ACICLOVIR IN THE PREVENTION OF ERPETIC POST OPERATIVE KERATITIS

Am J Ophthalmol. 2008 Feb; 145 (2): 198-202. doi: 10.1016 / j.ajo.2007.10.005.

Clinical trial that demonstrates the greatest efficacy of systemic aciclovi over topical ones in reducing the incidence of herpetic keratitis following keratoplasty.

HVAC RESISTANT HSV

Am J Med. 2006 May; 119 (5): e9-11.

Study that reaffirms the importance of evaluating the possible presence of HSV viral strains resistant to Acyclovir in order to establish suitable therapy also based on other topical antivirals such as the Imiquimod.

Method of use and dosage

ACY ®

Topical cream for 5% of Aciclovir

It is generally advisable to apply the appropriate quantity of medicine directly to the region affected by the infectious process four, five times a day at intervals of about four hours.

In order to optimize the therapeutic efficacy of the product it is recommended to start the treatment as early as possible after the onset of symptoms.

Warnings ACY ® Aciclovir

The correct use of ACY ® foresees the respect of different sanitary rules useful to limit the incidence of potential side effects.

In particular the patient should:

avoid contact of the drug with eyes and mucous membranes;
clean hands thoroughly after each application;
consult your doctor immediately if any side effects appear.

It is recommended to keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

The absence of studies able to fully characterize the safety profile of the drug for fetal health, requires the utmost caution in the use of ACY ® during pregnancy and in the subsequent period of breastfeeding.

For this reason, any therapy should be carried out in cases of inevitable necessity and always under strict medical supervision.