PEVISONE ® Econazole + Triamcinolone

PEVISONE ® is a drug based on Econazole + Triamcinolone

THERAPEUTIC GROUP: Antimycotics for topical use - association with corticosteroids

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Directions PEVISONE ® Econazole + Triamcinolone

PEVISONE ® is indicated in the treatment of dermatological diseases sustained by microorganisms sensitive to Econazole and characterized by an evident inflammatory / allergic component.

Mechanism of action PEVISONE ® Econazole + Triamcinolone

PEVISONE ® is a drug consisting of two different active ingredients, however, having complementary activity, useful in determining a prompt remission of the inflammatory symptoms present during dermatitis or skin diseases sustained by Gram negative microorganisms, dermatophytes, yeasts and molds.

The aforementioned activity is mediated by the presence of:

Econazole, imidazole derivative belonging to the category of antifungals, able to inhibit fungal proliferation, blocking the synthesis of ergosterol and interfering with the normal metabolic / energy processes of the cell;
Triamcinolone, a long-acting synthetic corticosteroid capable of blocking the inflammatory process upstream by reducing the production of arachidonic acid, a common precursor of numerous mediators known as prostanoids, capable of generating and sustaining the inflammatory insult.

Fortunately, topical use significantly reduces the various side effects associated with systemic therapy with these drugs.

Studies carried out and clinical efficacy

ECONAZOLE AND ZINC: enhancement of cytotoxic activity

Toxicol In Vitro. 2009 Jun; 23 (4): 610-6.

Experimental work that demonstrates how zinc can enhance the therapeutic activity of Econazole, significantly increasing the cytotoxic characteristics of the drug, and therefore offering new experimental ideas.

ECONAZOLE AND INHIBITION OF CHANNELS TO SOCCER

Br J Pharmacol. 2012 Nov; 167 (6): 1232-43.

Molecular biology work that demonstrates how? Econazole can carry out its therapeutic functions by also inhibiting cellular calcium channels, fundamental in the metabolic and structural homeostasis of the cell

ECONAZOLE AND VAGINAL CANDIDOSIS: new formulations

J Chemother. 2008 Jun; 20 (3): 336-40.

a very important pharmacokinetic study that demonstrates the effectiveness of the innovative release system of Econazole, represented by bioadhesive polymers, in the treatment of vaginal candidiasis, recording a significant improvement in the patient's clinical conditions.

Method of use and dosage

PEVISONE ®

Milk for dermatological use with 1 g of Econazole nitrate and 0.1 g of Triamcinolone acetamide.

It is advisable to apply PEVISONE ® on the surface affected by the inflammatory / infective process twice a day, morning and evening, taking care to gently massage the entire region for a maximum of eight days.

Warnings PEVISONE ® Econazole + Triamcinolone

In order to minimize the appearance of side effects rather than of microorganisms normally resistant to antifungal therapy, the appropriate use of the drug after medical consultation is recommended.

Prolonged use of PEVISONE ® may cause hypersensitivity reactions, sometimes clinically relevant.

It is recommended to keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

Given the presence of corticosteroids it would be preferable in principle to avoid the use of PEVISONE ® during pregnancy and in the subsequent period of breastfeeding.

However, should this be necessary, it should be done in cases of real need and under the strict supervision of a specialist doctor.

Interactions

Topical use of the drug significantly reduces the risk of clinically relevant drug interactions.

Contraindications PEVISONE ® Econazole + Triamcinolone

The use of PEVISONE ® is contraindicated in patients who are hypersensitive to the active ingredients or their excipients.

The presence of corticosteroids extends the contraindications even to patients suffering from tuberculosis, syphilis or skin diseases of vital origin.

Undesirable effects - Side effects

The cutaneous use of PEVISONE ® could determine the appearance of skin rash, burning, redness, rash, hypertrichosis, hypopigmentation and rarely skin atrophy.