TACHIPIRINA ® Paracetamol

TACHIPIRINA ® is a paracetamol based drug

THERAPEUTIC GROUP: Analgesics and antipyretic drugs

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications TACHIPIRINA ® Paracetamol

TACHIPIRINA ® is indicated in the symptomatic treatment of mild and modest painful states of various origins and in the treatment of febrile states.

Mechanism of action TACHIPIRINA ® Paracetamol

The great clinical success of TACHIPIRINA ®, which has made this drug one of the most used also in the field of self-medication, is due to the key role, as a non-steroidal analgesic, of paracetamol.

This active ingredient, while presenting a competitive inhibitory action against cyclooxygenases, enzymes involved in the conversion of arachidonic acid into chemical mediators with pro-inflammatory activity such as prostaglandins, is not classified among non-steroidal anti-inflammatory drugs but among analgesics and antipyretics.

This classification variation is essentially due to the selective therapeutic activity of paracetamol, which is able to inhibit a specific isoform of cyclooxygenases defined as COX 3 and expressed mainly at the neuronal level, where it regulates the concentrations of prostaglandin E2 and bradykinin.

These two molecules are involved respectively in the genesis of the fever, acting at the hypothalamic level through the increase of the thermal set-point, and in the pain transmission, by selectively activating the peripheral nerve endings.

However, the analgesic action of paracetamol seems to be carried out also at the central nervous level, probably exerting a direct action against the serotoninergic and dopaminergic systems, thus raising the pain threshold.

After its activity, paracetamol is metabolised to the liver level and excreted mainly via the kidney.

Studies carried out and clinical efficacy

1. THE PARACETAMOL IN THE POST-OPERATIVE PAIN

Cochrane Database Syst Rev. 2011 Oct 5; (10): CD007126.

A very important review that collects the results of 36 studies for over 3800 enrolled patients, which shows how intravenous administration of paracetamol can be effective in reducing post-operative pain.

2 .THE PARACETAMOL IN THE CONTROL OF PAIN DUE TO FRACTURES

Emerg Med Australas. 2009 Dec; 2 is vascular (hypotension);

Increased transaminases;

Hepato and nephrotoxicity.

The risk of paracetamol poisoning in hepatopathic and nephropathic patients also remains very high, the consequences of which could seriously compromise the patient's state of health.