ISOTREXIN® is a drug based on Isotretinonin and Erythromycin
THERAPEUTIC GROUP: Anti-acne preparations for topical use
IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects
Indications ISOTREXIN ® Isotretinoin + Erythromycin
ISOTREXIN® is used in the treatment of mild and moderate acne.
Mechanism of action ISOTREXIN ® Isotretinoin + Erythromycin
ISOTREXIN® is a drug consisting of two different active ingredients with complementary therapeutic activities, able to optimize the clinical efficacy of the drug.
More precisely, Isotretinonin, an acid derivative of vitamin A, performs a keratolytic and proliferative action by exfoliating the more superficial keratinized layers and controlling the sebaceous secretion of the gland, subsequently allowing a re-epithelization useful to uniform the superficial cutaneous layer.
Erythromycin on the other hand, a macrolide capable of inhibiting bacterial protein synthesis by structurally interfering with the 50S ribosomal subunit, is able to control the proliferation of Proprionibacterium acnes, a microorganism involved in the pathogenesis of acne and responsible in part for the phlogistic evolution of lesions comedy cutaneous.
The combination of the two active ingredients therefore allows to optimize the therapeutic efficacy of the drug, guaranteeing however an adequate control of the potential side effects classically linked to systemic therapy and instead minimized by topical use.
Studies carried out and clinical efficacy
ISOTRETINONINE AND ANTIBIOTIC: GREAT CLINICAL EFFICACY
Clin Drug Investig. 2011; 31 (8): 599-604. doi: 10.2165 / 11539570-000000000-00000.
Work that shows how the addition of an antibiotic to Isotretinonin can guarantee better clinical efficacy, significantly reducing the extent of inflammatory lesions and the severity of the pathology itself.
ISOTRETINONINE AND RESISTANT MICRORGANISMS
Br J Dermatol. 2005 Dec; 153 (6): 1126-36.
Interesting work that demonstrates how oral treatment with Isotretinonin can be so effective also to control the proliferation of resistant antibiotic bacteria significantly improving the quality of life of the patient suffering from acne.
ERYTHROMYCIN AND LIGHT PULSED IN THE TREATMENT OF ACNE
Adv Biomed Res. 2012; 1: 70. doi: 10.4103 / 2277-9175.102974. Epub 2012 Oct 31.
Study demonstrating how the association of pulsed light with topical antibiotic treatment with Erythromycin can significantly improve the extent of inflammatory lesions present in patients with moderate or severe acne
Method of use and dosage
ISOTREXIN®
Topical gel with 0.05% Isotretinonin and 2% Erythromycin.
The correct use of the drug, which should always be carried out under strict medical supervision, generally involves the application of the appropriate amount of gel directly on the skin region affected by the pathological event once or twice a day, for several weeks.
Warnings ISOTREXIN ® Isotretinoin + Erythromycin
The use of ISOTREXIN® must necessarily be preceded by a careful medical examination in order to clarify the pathological event in progress and any prescriptive appropriateness.
In order to avoid the possible occurrence of adverse reactions, the patient receiving ISOTREXIN® should:
- avoid ingestion and contact of the gel with eyes and mucous membranes;
- cleanse your hands thoroughly after using the medicine;
- avoid exposure of the treated area to ultraviolet rays;
- avoid using the drug in the event of burns or other dermatological diseases.
It is also recommended to keep the drug out of the reach of children.
PREGNANCY AND BREASTFEEDING
Given the absence of clinical trials able to fully clarify the potential teratogenic or toxic effects of the active ingredients contained in ISOTREXIN® for the fetus and the particularly worrying results of some experimental studies, it would be appropriate to extend the aforementioned contraindications to the use of drug also during pregnancy and subsequent breastfeeding period.
Interactions
The patient receiving ISOTREXIN® should avoid the simultaneous intake of cortisone and the application of other products topically, especially those with keratolytic activity.
Contraindications ISOTREXIN ® Isotretinoin + Erythromycin
The use of ISOTREXIN® is contraindicated in patients hypersensitive to the active ingredient or to one of its excipients and in patients suffering from dermatological diseases.
Undesirable effects - Side effects
Numerous clinical trials and extensive post-marketing experience have shown how the use of Isotretinonin, especially in subjects predisposed or when prolonged for particularly long periods, can determine the onset of local adverse reactions such as burning, irritation, erythema, pain and itching .
Fortunately, the most clinically relevant events and generally associated with hypersensitivity reactions to the drug are rarer.
Note
ISOTREXIN® is a prescription-only drug.
