Information on Nitric Oxide Booster - EAS
Nitric Oxide Booster - EAS
Food supplement based on Arginine alpha keto-glutarate and niacin
FORMAT
120 cpr bottle
COMPOSITION
Arginine alpha keto-glutarate (A-AKG)
Niacin
Emulsifiers: E460 (cellulose), E463 (Hydroxypropyl cellulose), soy lecithin.
CONTAINS SOYBEAN
One dose (one tablet) contains: L - Arginine alpha ketoglutarate 1000 mg
Niacin 4.5 mg
L-Arginine alpha keto glutarate (AAKG) - L arginine salt obtained synthetically by association of two arginine molecules with one of alpha keto glutarate. This alpha keto acid is very important from the metabolic point of view, as it represents an intermediate between anabolic and catabolic reactions, being able to vary its metabolic destiny according to physiological needs. In the case of energy need, the alpha keto glutarate can effectively supply the krebs cycle, but at the same time it can be part of the synthesis of glutamate, glutamine, proline and of course also arginine. This last amino acid, presents a multiplicity of functions, which although synthesized endogenously, make it a conditionally essential amino acid. In addition to protein synthesis, arginine is included in the synthesis of creatine, in the gluconeogenic process, in the synthesis of collagen, in the ammonia detoxification process, in the strengthening of the immune defenses and in the much discussed ability to increase GH secretion. At the same time, arginine is part of another very important process, which is the production of nitric oxide . This gas is produced from arginine from different isoforms of the enzyme nitric oxide synthetate (NOS). On a muscular level, the constitutive forms of this enzyme, namely the endothelial isoform and the neuronal isoform, in a calcium dependent manner, guarantee the correct production of nitric oxide, supporting on the one hand the vasodilatory process, which guarantees a better influx of oxygen and nutrients, and on the other, an increase in nutrient intake capacity by muscle fibers.
It must be considered that there is also a third isoform, called inducible, which is the basis of the cytotoxic action that occurs following the penetration of pathogenic agents, and that is potentially dangerous, as it exposes the body to oxidative damage.
Niacin - vitamin also known as vitamin PP or vitamin B3; it is present in plants (mainly whole grains), in the form of nicotinic acid, and in animals (meats), in the form of nicotinamide. Both forms are absorbed at the gastric and intestinal level through a transport facilitated with sodium, and conveyed to the various tissues, some of which can be obtained from tryptophan and lysine. This molecule is part of the constitution of NAD and NADP, two very important electron acceptors, involved in many metabolic reactions.
In this case, the role of cofactor of the enzyme nitric oxide synthase should be emphasized.
Niacin also appears to be involved in the protection of pancreatic beta cells in type I diabetes, in the improvement of the lipidemic profile and in the protection from cardiovascular diseases (at high dosages).
Deficiencies of these vitamins, very rare, give rise to a pathological condition known as pellagra, characterized by dermatitis, mental and cognitive disorders.
For a man in adulthood, the LARN, recommend an intake of about 20mg / day, considering that doses higher than 3000mg, can originate a classic gastro intestinal symptomatology.
Product features Nitric Oxide Booster - EAS
Compared to other arginine supplements, formulated in the hope of increasing GH levels, this product, as can easily be seen from the name, was born as a stimulator of nitric oxide production.
The increase of nitric oxide in muscle, during physical activity, should increase the vascular caliber, facilitating the arrival of oxygen and nutrients and activating the muscle fiber upon correct reception. In physical and athletic terms, this would result in an improvement in athletic performance, through improved muscular trophism with consequent reduction in fatigue.
Suggested use by the company - Nitric Oxide Booster - EAS
Take one tablet before the main meal
Use in sports practice Nitric Oxide Booster - EAS
Arginine: The various studies carried out on athletes use quite various dosages, from 2 to 8 grams per day (best results obtained at dosages of 3 gr / day), to improve physical performance and reduce the feeling of fatigue.
Studies show that the simultaneous administration of creatine and arginine (creatine 0.075 g / kg - Arginine alpha keto-glutarate 0.1 gr / kg) for 10 days, may determine a better ergogenic boost, with a relative improvement in muscular endurance and maximum peak power.
At the same time, the intake of arginine and antioxidants appears to increase the anaerobic threshold by 16%, delaying the feeling of fatigue.
Another possible association is with branched chain amino acids; in fact, a study shows that the supplementation of 2g of BCAA with 0.5g of Arginine, can reduce proteolysis following intense muscular exercise.
Rationale for use - Nitric Oxide Booster - EAS
Several studies report an improvement in athletic performance, in terms of maximum peak strength, endurance, increased anaerobic threshold, reduced lactate and muscle fatigue, following administration of arginine. These benefits are obtained through mechanisms that are not yet fully known; it must be remembered, however, that in other studies the integration does not seem to lead to any result.
At the same time, other studies show a marked improvement in athletic performance in heart patients or those with pulmonary hypertension, as well as a direct protective effect of nitric oxide induced by the administration of L arginine on the skeletal muscle fiber exerted by rats. Although these studies give a strong indication of the role of nitric oxide in mediating these reactions, there is still no direct correlation in healthy individuals subjected to exercise, including L-arginine, nitric oxide and improved athletic performance.
It is necessary to consider. in fact, that the production of nitric oxide starting from arginine is regulated by complex intracellular events, which ignore the exclusive availability of the substrate (arginine), and which see the interest of numerous other pathways.
Side Effects Nitric Oxide Booster - EAS
The most common side effects, recorded in large doses, are vomiting, diarrhea and abdominal cramps at doses above 9 grams per day.
Massive doses, generally higher than 30 g, can originate nephrotoxicity, hypotension and headaches.
Not enough data on OKG.
Precautions for use Nitric Oxide Booster - EAS
The product is contraindicated in cases of renal or hepatic disease, cardiovascular disease and / or hypertension, in pregnancy, during lactation and under 12 years and adolescents not yet trained.
This article, elaborated on the critical re-reading of scientific articles, university texts and common practice, is for informational purposes only and is therefore not a medical prescription. It is therefore always necessary to consult your doctor, nutritionist or pharmacist before starting to use any kind of supplement . Further information on the critical analysis of Nitric Oxide Booster - EAS.
| BIBLIOGRAPHY |
L-arginine reduces exercise-induced increase in plasma lactate and ammonia. Schaefer A, Piquard F, Geny B, Doutreleau S, Lampert E, Mettauer B, Lonsdorfer J. Int J Sports Med. 2002 Aug; 23 (6): 403-7. L-arginine supplementation prolongs exercise capacity in congestive heart failure. Bednarz B, Jaxa-Chamiec T, Gebalska J, Herbaczyńska-Cedar K, Ceremuzyński L. Kardiol Pol. 2004 Apr; 60 (4): 348-53. English, Polish. L-arginine supplementation improved exercise capacity after a heart transplant. Doutreleau S, Rouyer O, Di Marco P, Lonsdorfer E, Richard R, Piquard F, Geny B. Am J Clin Nutr. 2010 May; 91 (5): 1261-7. Epub 2010 Mar 3. [Protective effect of nitric oxide on cytoskeletal proteins in skeletal muscles under eccentric exercise] Lomonosova IuN, Zhelezniakova AV, Bugrova AE, Zhiriakova AV, Kalamkarov GR, Nemirovskaia TL. Biofizika. 2009 May-Jun; 54 (3): 515-21. Russian. Hemodynamic and vascular response to resistance exercise with L-arginine. Fahs CA, Heffernan KS, Fernhall B. Med Sci Sports Exerc. 2009 Apr; 41 (4): 773-9. Regulation of nitric oxide production in health and disease. Luiking YC, Engelen MP, Deutz NE. Curr Opin Clin Clin Metab Care. 2010 Jan; 13 (1): 97-104. Review. Role of L-arginine in nitric oxide production in health and hypertension. Rajapakse NW, Mattson DL. Clin Exp Pharmacol Physiol. 2009 Mar; 36 (3): 249-55. Epub 2008 Nov 28. Review. J Physiol Pharmacol. 2008 Aug; 59 Suppl 1: 91-106. Harrison AP, Pierzynowski SG. Amino Acids. 2009 May; 37 (1): 153-68. Epub 2008 Nov 23. Arginine metabolism and nutrition in growth, health and disease. Wu G, Bazer FW, Davis TA, Kim SW, Li P, Marc Rhoads J, Carey Satterfield M, Smith SB, Spencer TE, Yin Y. Curr Opin Clin Clin Metab Care. 2008 Jan; 11 (1): 50-4. Growth hormone, arginine and exercise. Kanaley JA. Ann Pharmacother. 2001 Jun; 35 (6): 755-64. L-arginine in the management of cardiovascular diseases. Cheng JW, Baldwin SN. Risk assessment for the amino acids taurine, L-glutamine and L-arginine. Shao A, Hathcock JN. Regul Toxicol Pharmacol. 2008 Apr; 50 (3): 376-99. Epub 2008 Jan 26. Review. Chronic but not acute oral L-arginine supplementation delays the ventilatory threshold during heart failure patients. Doutreleau S, Mettauer B, Piquard F, Schaefer A, Lonsdorfer E, Richard R, Geny B. Can J Appl Physiol. 2005 Aug; 30 (4): 419-32. Use of amino acids as growth hormone-releasing agents by athletes. Chromiak JA, Antonio J. Nutrition. 2002 Jul-Aug; 18 (7-8): 657-61. Review. Arginine and antioxidant supplement on performance in elderly male cyclists: a randomized controlled trial. Chen S, Kim W, Henning SM, Carpenter CL, Li Z. J Int Soc Sports Nutr. 2010 Mar 23; 7 (1): 13. [Epub ahead of print] Creatine, arginine alpha-ketoglutarate, amino acids, and medium-chain triglycerides and endurance and performance. Little JP, Forbes SC, Candow DG, Cornish SM, Chilibeck PD. Int J Sport Nutr Exerc Metab. 2008 Oct; 18 (5): 493-508. No effect of short-term arginine supplementation on nitric oxide production, metabolism and performance in intermittent exercise in athletes. Liu TH, Wu CL, Chiang CW, Lo YW, Tseng HF, Chang CK. J Nutr Biochem. 2009 Jun; 20 (6): 462-8. Epub 2008 Aug 15. Int J Sport N. 1993 Sep; 3 (3): 298-305. Failure of commercial oral amino acid supplements to increase serum growth hormone concentrations in male body-builders.Lambert MI, Hefer JA, Millar RP, Macfarlane PW . Effect of L-arginine supplementation on human growth hormone and insulin-like growth factor in adults Fayh AP, Friedman R, Sapata KB, Oliveira AR. Arq Bras Endocrinol Metabol. 2007 Jun; 51 (4): 587-92. Portuguese. Oral arginine attenuates the growth hormone response to resistance exercise. Collier SR, Collins E, Kanaley JA. J Appl Physiol. 2006 Sep; 101 (3): 848-52. Epub 2006 Jun 1. Adverse gastrointestinal effects of arginine and related amino acids. Grimble GK. J Nutr. 2007 Jun; 137 (6 Suppl 2): 1693S-1701S. Review. Oral arginine does not stimulate basal or augmentation exercise-induced GH secretion in either young or old adults. Marcell TJ, Taaffe DR, Hawkins SA, Tarpenning KM, Pyka G, Kohlmeier L, Wiswell RA, Marcus R. J Gerontol A Biol Sci Med Sci. 1999 Aug; 54 (8): M395-9. Br J Clin Pharmacol. 1999 Mar; 47 (3): 261-6. Tangphao O, Grossmann M, Chalon S, Hoffman BB, Blaschke TF. Branched-chain amino acids and arginine supplementation attenuated skeletal muscle proteolysis induced by moderate exercise in young individuals. Matsumoto K, Mizuno M, Mizuno T, Dilling-Hansen B, Lahoz A, Bertelsen V, Münster H, Jordening H, Hamada K, Doi T. Int J Sports Med. 2007 Jun; 28 (6): 531-8. Epub 2007 May 11. Erratum in: Int J Sports Med. 2007 Jul; 28 (7): 63 Effects of Arginine-Based Supplements on the Physical Working Capacity at the Fatigue Threshold. Camic CL, Housh TJ, Zuniga JM, Hendrix RC, Mielke M, Johnson GO, Schmidt RJ. J Strength Cond Res. 2010 Apr 9. Curr Med Res Opin. 1981; 7 (7): 475-81. A study of growth hormone release in man after oral administration of amino acids.Int J Sport Nutr. 1993 Sep; 3 (3): 298-305. Failure of commercial oral amino acid supplements to increase serum growth hormone concentrations in male body-builders.Lambert MI, Hefer JA, Millar RP, Macfarlane PW. |
