FARGAN ® Promethazine

FARGAN ® is a drug based on Promethazine

THERAPEUTIC GROUP: Antipruriginosi, including antihistamines, anesthetics, etc.

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications FARGAN ® Promethazine

FARGAN ® is successfully used in the treatment of itchy skin forms and in localized skin irritation phenomena characterized by redness, burning and sunburn.

Mechanism of action FARGAN ® Promethazine

FARGAN ® is a medicinal product based on Promethazine, an antagonist of the histamine H1 receptor and therefore has a significant antihistamine effect that is manifested in the antiedematous, antipruritic and modestly anti-inflammatory activity of the drug.

However, topical application of this active ingredient limits some of the collateral effects classically related to systemic therapy with antihistamines such as Promethazine, such as the sedative effect against the Central Nervous System, due to the ability to easily cross the blood-brain barrier, making thus the topical application of FARGAN ® generally safe and well tolerated.

Studies carried out and clinical efficacy

NEUROPROTECTIVE EFFECT OF PROMETAZINE

Neurochem Int. 2010 Jan; 56 (2): 208-12. doi: 10.1016 / j.neuint.2009.10.006. Epub 2009 Oct 21.

Interesting work that describes the neuroprotective effect of Promethazine, against gabaergic striatal neurons subjected to damage induced by strong oxidizing agents.

ANTIEMETIC EFFECT OF PROMETAZINE

Can Vet J. 2012 Feb; 53 (2): 193-5.

Experimental study that demonstrates one of the complementary therapeutic effects of Promethazine, namely the antiemetic one, probably associated with the effects of this active principle on the central nervous system.

NEW DELIVERY SYSTEMS OF PROMETAZINA

Int J Pharm Compd. 2005 May-June; 9 (3): 242-246.

Recent pharmacokinetic study that seeks to optimize the properties of Promethazine by formulating a new delivery system consisting of organic compounds such as lecithin. These studies are aimed at obtaining drugs capable of guaranteeing a gradual and prolonged release of the active principle in order to reduce the frequency of application, making therapy easier.

Method of use and dosage

FARGAN ®

Cream for cutaneous use of 2 g of Promethazine for 20 g of product.

Generally, better if prescribed by your doctor, it is recommended to apply the appropriate amount of cream, directly on the region affected by the symptoms, 3-4 times a day, taking care to gently massage the region.

Warnings FARGAN ® Promethazine

The use of FARGAN ® should be preceded by a careful medical examination aimed at clarifying the origin of the complained symptomatology and any prescriptive appropriateness.

Prolonged use of this medicine could cause the appearance of sensitization phenomena such as to worsen the present symptoms, thus delaying the healing and healing of skin lesions.

The patient receiving FARGAN ® should comply with a series of sanitary regulations useful for optimizing the therapeutic efficacy of the drug, while limiting the onset of potential side effects.

Given the photosensitising power of Promethazine, the patient receiving FARGAN ® should avoid exposure of the treated area to ultraviolet radiation.

It is recommended to keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

Given the absence of studies able to verify the safety profile of the drug for fetal and infant health it is recommended to use FARGAN ® only in cases of real need and always under the strict supervision of your doctor.

Interactions

No clinically relevant drug interactions are currently known.

Contraindications FARGAN ® Promethazine

The use of FARGAN ® is contraindicated in patients with hypersensitivity to the active ingredient or to one of its excipients, or with particularly showy and secreting skin diseases.

Undesirable effects - Side effects

The use of FARGAN ®, especially when prolonged over time, could lead to the appearance of local adverse reactions, fortunately of a transitory nature.