ZINERYT ® Erythromycin + Zinc

ZINERYT ® is a drug based on Erythromycin + zinc micronized dihydrate acetate

THERAPEUTIC GROUP: Antibacterials - Antimicrobial for acne treatment

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications ZINERYT © Erythromycin + Zinc

ZINERYT ® is indicated for the topical treatment of acne vulgaris.

Mechanism of action ZINERYT © Erythromycin + Zinc

ZINERYT © is a medicinal specialty widely used in dermatology in the topical treatment of acne vulgaris.

Among the innumerable conditions predisposing to the typical inflammatory lesions present in this pathology it is possible to find a high concentration of free fatty acids, the cause of obstruction of the sebaceous glands with a consequent comedogenic phlogistic response.

Antibiotic treatment with erythromycin has been shown to be particularly effective in these cases, by reducing bacteriostatic activity, the bacterial skin charge mainly represented by Propionibacetrium acnes and Staphylococcus auerus, therefore also the relative secretion of free fatty acids.

However, recent studies have shown that erythromycin can also perform an indirect anti-inflammatory action, reducing the production by the aforementioned microbial species of chemotactic elements, able to recall cellular elements of phlogosis.

In this regard, the addition of zinc proved to be supportive, appreciably reducing the local concentration of inflammatory cytokines such as IL 1 and IL 6, thereby modulating the phlogistic capacities of these molecules.

At the same time, the low systemic absorption of the active ingredients contained in ZINERYT © significantly reduces the side effects of the therapy and the possible complications.

Studies carried out and clinical efficacy

1 ERYTHROMYCIN AND ZINC IN THE ACNE TREATMENT

Recent study that demonstrates how the combined treatment with erythromycin and zinc, can be effective and well tolerated in patients suffering from acne vulgaris, guaranteeing good therapeutic resolution in a few weeks of treatment.

2 . EFFECTIVENESS OF THE ASSAY AT 4% OF ERYTHROMYCIN

Dutch study that tests the effectiveness of the medicinal specialty Zineryt, highlighting a greater efficacy of the erythromycin dosage at 4% in improving the degree of acne severity.

3. ZINCO AND PHARMACOCINETIC PROPERTIES OF ERITROMYCIN

Pharmacokinetic and pharmacodynamic study that shows how the presence of zinc at the same time as that of erythromycin can improve persistence in the antibiotic, also allowing a greater ability to penetrate the stratum corneum.

Method of use and dosage

ZINERYT ©

Powder and solvent for dermal solution containing 50 mg of erythromycin and 12 mg of zinc acetate per ml of solution.

It is advisable to apply the correct amount of solution on the area to be treated twice a day.

In most cases the treatment for 10-12 weeks is generally effective.

Warnings ZINERYT © Erythromycin + Zinc

The erythromycin contained in ZINERYT © could be responsible for sensitization phenomena on allergic basis and photosensitization.

For this reason it is recommended to stop the treatment if signs and symptoms of hypersensitivity appear, avoiding direct exposure of the treated area to ultraviolet rays.

Avoid direct contact between the medicine and mucous membranes.

PREGNANCY AND BREASTFEEDING

Despite the low systemic absorption that characterizes this medicine, it would be preferable to limit its use during pregnancy and in the subsequent period of breastfeeding, exclusively in cases of real and inevitable necessity.

Interactions

Local adverse reactions may appear following the simultaneous application of potentially irritating detergents or creams.

Undesirable effects - Side effects

The low systemic absorption of the active principle limits the occurrence of side effects only to the local level with the possible appearance of desquamation, photosensitization, greasiness, burning sensation and itching.