CITRIZAN ® Catalase

CITRIZAN ® is a drug based on equine catalase

THERAPEUTIC GROUP: Enzymes - Eparinoid for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications CITRIZAN ® Catalase

CITRIZAN ® is indicated to facilitate the healing of chronic skin ulcers, burns and traumatic wounds.

Mechanism of action CITRIZAN ® Catalase

The therapeutic activity of CITRIZAN ® is evidently linked to the presence of its active ingredient, catalase, an enzyme endowed with a marked antioxidant power generally within the pull of endogenous antioxidants.

Used topically, this enzyme is concentrated at the wound level, where it carries out its biological activity by breaking down hydrogen peroxide into water and oxygen, thus determining:

a reduction of oxygen free radicals, and in particular of hydrogen peroxide, an oxidizing element responsible for the oxidative damage following a traumatic event;
an increase in the local oxygen content, necessary for the optimization of the shelter processes such as the deposition of collagen fibers and the consequent healing of the wound.

The absence of systemic absorption clearly makes the use of CITRIZAN ® safe and free of clinically relevant side effects.

Studies carried out and clinical efficacy

CATALASE IN GEL AND VITILIGINE

FASEB J. 2013 Apr 29. [Epub ahead of print]

A recent study that evaluates the possibility of using catalase-based gels in the treatment of non-segmental Vitiligo, given the pathogenesis of the same characterized by a strong oxidizing impact, mediated precisely by hydrogen peroxide and reactive nitrogen derivatives.

CATALASE AND CORNEA

Invest Ophthalmol Vis Sci. 1993 Aug; 34 (9): 2752-60.

Interesting work that demonstrates the ability of mucosal endogenous antioxidant systems, most likely also constituted by catalase, to effectively detoxify the cornea and conjunctiva from hydrogen peroxide.

CHLOROXYLOXOL IN UROPATOGENIC INFECTIONS

Clin Microbiol Infect. 2008 Feb; 14 (2): 190-2. Epub 2007 Nov 28.

Clinical trial that tests the effectiveness of Catalase-based gels in the treatment of second-degree superficial burns, comparing it to that of other drugs topically, and verifying the excellent tolerability, however, against a modest efficacy.

Method of use and dosage

CITRIZAN ®

Topical gel with 800, 000 IU Catalase per 100 g of product.

Generally the application of the correct amount of gel, necessary to cover the burned or ulcerated region, once or twice a day depending on the medical indications, is able to optimize the wound healing and healing process.

Warnings CITRIZAN ® Catalase

The use of CITRIZAN ® must necessarily be preceded by a careful medical examination aimed at assessing the extent of the lesion and the prescriptive appropriateness of the drug.

It is necessary to thoroughly clean the affected region before applying the drug, taking care to avoid its use on infected wounds, for which an eventual antibiotic therapy would also be appropriate.

Prolonged use of CITRIZAN ®, like any other topical product, could cause the onset of adverse reactions also from hypersensitivity to the drug.

PREGNANCY AND BREASTFEEDING

The use of CITRIZAN ® during pregnancy and in the subsequent period of breastfeeding should be carried out exclusively in cases of real need and under the strict supervision of your doctor.

Interactions

It is recommended to avoid contextual use of other drugs topically

Contraindications CITRIZAN ® Catalase

The use of CITRIZAN ® is contraindicated in patients who are hypersensitive to the active substance or to one of its excipients.

Undesirable effects - Side effects

The appropriate use of CITRIZAN ® is generally safe and well tolerated, although from various clinical trials and post-marketing experience there are local side effects characterized by irritation, erythema and dermatitis.

It is also useful to consider the heterologous nature of catalase, sometimes responsible for hypersensitivity reactions.