VITAN ® Retinol

VITAN® is a drug based on Retinol

THERAPEUTIC GROUP: Ophthalmology

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications VITAN ® Retinol

VITAN® is indicated as an adjunct in the treatment of corneal lesions, blepharitis, keratoconjunctivitis, keratitis and corneal ulcers.

Mechanism of action VITAN ® Retinol

VITAN® is a drug based on Retinol, more commonly known as vitamin A, an important factor in the regulation of cell growth and differentiation, especially for epithelial cells.

Its mechanism of action, characterized by the ability to adequately regulate the expression of transcription factors involved in the regulation of differentiation processes is today almost entirely clarified so as to associate to its local deficiencies pathological conditions such as dry eye, keratomalacia, lesions and corneal ulcers .

The role of vitamin A as an antioxidant is also fundamental, therefore important in preventing the damage caused by reactive oxygen species.

Studies carried out and clinical efficacy

VITAMIN A IN POST-OPERATION PHASES

Clin Ophthalmol. 2013; 7: 1913-1918. Epub 2013 Sep 24.

Recent study showing that topical supplementation with vitamin A does not seem to produce improvements in terms of re-epithelialization and post-operative pain regression following keratectomy.

LACK OF VITAMIN A and LOCAL EFFECTS

Doc Ophthalmol. 2013 Jul 31. [Epub ahead of print]

Diagnostic imaging study that studies the functional anatomical events related to vitamin A deficiency, demonstrating lesions both at the corneal and retinal level with dysfunction and accumulation of sub retinal deposits.

VITAMIN A AT HIGH DOSAGE

Public Health Nutr. 2013 Jun 17: 1-6. [Epub ahead of print]

Study demonstrating the resolution of a characteristic syndrome with supplementation with high doses of Vitamin A in Indian patients, thus extending the possible therapeutic indications to the use of vitamin A.

Method of use and dosage

VITAN®

Ophthalmic ointment with 25000 IU of Retinol per 100 g of product.

Unless otherwise prescribed by a doctor, 2-3 applications per day are generally recommended directly in the conjunctival sac.

Warnings VITAN ® Retinol

The use of VITAN® should be preceded by a careful medical examination in order to clarify the origin of the eventual lesion and the consequent appropriateness of the Retinol.

As with any other product the prolonged use of the drug by ophthalmic means, could cause the appearance of local side effects from hypersensitivity to the product.

PREGNANCY AND BREASTFEEDING

Although the potential side effects of fetal health related to topical Retinol use are not known, the use of VITAN® during pregnancy and subsequent breastfeeding should be justified by real needs and should always be supervised by one's own gynecologist.