LOMEXIN ® Fenticonazole

LOMEXIN ® is a drug based on Fenticonazole nitrate

THERAPEUTIC GROUP: Antimycotics for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications LOMEXIN ® Fenticonazole

LOMEXIN ® is successfully used in the treatment of dermatomycoses sustained by dermatophytes, yeasts and fungi, in infections of the scalp, in onychomycosis, in cutaneous candidiasis and in the vaginal mucosa and in Pityriasis versicolor.

Mechanism of action LOMEXIN ® Fenticonazole

LOMEXIN ® is a medicinal product based on Fenticonazole, an active ingredient belonging to the vast family of imidizazole derivatives with which it clearly shares both the static fungicidal and fungicidal activity and the bactericidal activity directed towards Gram positive organisms.

The clinical efficacy of this active ingredient is linked to the inhibitory action against the enzyme 14 alpha methyl lanosterol demethylase, an enzyme involved in the biosynthesis of Ergosterol, an important membrane molecule in preserving the structural and functional properties of the plasma membrane.

The inhibition of this enzyme in addition to seriously compromising the biological properties of the plasma membrane induces a slowing down of all biosynthetic activities due to the accumulation of potentially toxic catabolites.

The aforementioned activities materialize with the death of the microorganism and the consequent remission of the complained symptoms.

Studies carried out and clinical efficacy

FENTICONAZOLE CLINIC

Drugs. 2008; 68 (15): 2183-94.

Very interesting review that reaffirms the usefulness of Fenticonazole in the treatment of dermatomycoses and vaginal candidiasis, generally guaranteeing a prompt remission of the symptomatology in the face of usually well tolerated side effects.

FENTICONAZOLE AND CANDIDOSIS

Contracept Fertil Sex. 1997 May; 25 (5): 396-403.

Study demonstrating how the use of Fenticonazole can be effective in the treatment of vaginal mucosal candidiasis, controlling the classic symptoms associated with this disease and modulating the in vitro secretion of some proteinases involved in the genesis of histological damage.

FENTICONAZOLE SAFETY

Arzneimittelforschung. 1990 Mar; 40 (3): 329-31.

Study that reaffirms the safety of Fenticonazole used topically, not showing any type of potentially toxic reaction in the 12 subjects tested.

Method of use and dosage

FALVIN ®

Cream for cutaneous use at 2% of Fenticonazole nitrate;

Solution with nebulizer of 2 g of Fenticonazole per 100 ml of solution;

Sprinkling powder at 1 or 2% of Fenticonazole nitrate;

Dermoschiuma 2% of Fenticonazole nitrate;

2% lotion of Fenticonazole nitrate.

Generally it is recommended to apply the appropriate quantity of the drug directly on the region affected by the infection process once or twice a day, after having thoroughly cleaned the area to be treated.

The choice of pharmaceutical format obviously depends on the region affected by the infectious process and must necessarily be suggested by the doctor.

Warnings LOMEXIN ® Fenticonazole

The use of LOMEXIN ® should be preceded by a careful medical examination and accompanied by continuous medical monitoring.

At the same time the patient should take a series of precautions to limit the occurrence of side effects and to optimize therapeutic efficacy.

Avoid contact of the drug with the eyes, thoroughly cleanse the skin region to be treated before applying the drug, cleanse your hands thoroughly after application to avoid residual residues, avoid direct exposure to ultraviolet radiation and carefully follow the Medical indications are the most important precautions to be observed.

PREGNANCY AND BREASTFEEDING

The aforementioned contraindications to the use of LOMEXIN ® also extend to pregnancy and the subsequent period of breastfeeding, given the absence of studies able to better characterize the safety profile of Fenticonazole for fetal health.

Interactions

Drug interactions worthy of clinical note are currently unknown.

Contraindications LOMEXIN ® Fenticonazole

The use of LOMEXIN ® is contraindicated in patients who are hypersensitive to the active substance or to one of its excipients.

Undesirable effects - Side effects

The use of LOMEXIN ® especially when prolonged for a long time, could determine the onset of local and transient side effects such as redness, burning and erythema.

Fortunately, clinically relevant side effects are rarer.