POLARAMIN ® Desclofeniramina

POLARAMIN ® is a drug based on Desclofeniramina maleate

THERAPEUTIC GROUP: Antipruriginosi, including antihistamines, anesthetics, etc.

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications POLARAMIN ® Desclofeniramina

POLARAMIN ® is indicated for the symptomatic treatment of pruritic dermatitis, erythema and sun and insect bites.

Mechanism of action POLARAMIN ® Desclofeniramina

Desclofeniramina, the active ingredient of POLARAMIN ®, is the dextrorotatory isomer of the more well-known Chlorfeniramine, which therefore has effective anticholinergic, antihistamine and modestly sedative biological properties.

The aforementioned therapeutic properties can be attributed to the ability of the active ingredient to compete with histamine for binding to H1 receptors, thus inhibiting the biological activity of histamine and controlling vasodilation, inflammation, pain and edema induced by this broker.

The topical use of POLARAMIN ® also limits the systemic absorption of the active ingredient, significantly reducing the potential side effects classically linked to the systemic use of antihistamines such as those affecting the central nervous system.

All this makes the administration of POLARAMIN ® effective and safe for the treatment of minor skin conditions such as itchy dermatitis, insect bites and sunburn, supported by biological mediators such as histamine.

Studies carried out and clinical efficacy

THE TREATMENT OF GYNECOLOGICAL ITCHING

Ann Pharmacother. 1994 Jan; 28 (1): 17-20.

Italian study that evaluates the effectiveness of Desclorfeniramina in the treatment of gynecological pruritus, evaluating the efficacy and safety of this active ingredient compared to others commonly used. Unfortunately the results obtained do not allow defining the safety profile of the medicinal product for fetal health.

DESCLORPHENIRAMINE HEPATITIS

Gastroenterol Clin Biol. 1998 Oct; 22 (10): 831-2.

Yet another case report that denounces the appearance of acute hepatitis in a patient undergoing Desclorfeniramina therapy, reiterating the importance of compliance with therapeutic indications and relative contraindications

DESCLORPHENIRAMINE ANAPHYLASSES

Eur J Dermatol. 2007 Mar-Apr; 17 (2): 170-1. Epub 2007 Mar 2.

Case report denouncing the appearance of an anaphylactic reaction to desclorpheniramine, so severe as to require hospitalization and immediate cessation of therapy.

Method of use and dosage

POLARAMIN ®

Dermatological cream with 1% Desclorfeniramina maleate.

It is generally recommended to apply the appropriate amount of cream directly on the skin region characterized by the pathological process 2-3 times a day, taking care to gently massage the area to ensure complete absorption.

Warnings POLARAMIN ® Desclofeniramina

Although the use of POLARAMIN ® is generally well tolerated, it is advisable for the patient to comply with certain hygienic-sanitary rules useful for limiting the occurrence of potential side effects and for optimizing therapeutic efficacy.

Thoroughly clean your hands after applying the cream, avoid contact of the medicine with eyes and mucous membranes, avoid applying the cream on particularly large cutaneous regions affected by exuding and secreting pathological processes, avoid direct exposure to solar radiation. only the main warnings for the use of POLARAMIN ®.

It is generally recommended to keep the drug out of the reach of children.

PREGNANCY AND BREASTFEEDING

The use of POLARAMIN ® during pregnancy and in the subsequent period of breastfeeding should take place under the strict supervision of your doctor and only in case of real need.

Interactions

Drug interactions worthy of clinical note are currently unknown.

Contraindications POLARAMIN ® Desclofeniramina

The use of POLARAMIN ® is contraindicated in patients who are hypersensitive to the active substance or to one of its excipients.

Undesirable effects - Side effects

The use of POLARAMIN ®, above all when prolonged for a long time, could determine the appearance of local and transient adverse reactions such as burning, rashes, dry skin and photosensitivity.