LENIL ® is a drug based on Chlorhexidine dihydrochloride
THERAPEUTIC GROUP: Antiseptics and disinfectants
IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects
Indications LENIL ® Clorexidina
LENIL ® is indicated for the disinfection of injured skin.
Mechanism of action LENIL ® Chlorhexidine
Chlorhexidine, active ingredient of LENIL ®, is a biguanide molecule structurally characterized by the presence of positively charged residues and highly lipophilic groups, capable of interacting with high affinity with the cell membrane of different microorganisms.
In fact used topically, Chlorhexidine acts as a detergent of the plasma membrane, causing the formation of pores that alter the normal cellular network, resulting in the consequent loss of functionality of the enzymes involved in the metabolism of the microorganism.
At higher doses the same active principle is able to condense the intracellular environment, causing a total block of cellular activity and thus carrying out a relevant bactericidal action.
Different studies show how this antiseptic can be effective against Gram positive and Gram negative bacteria, but also against certain fungi and yeasts such as Candida albicans.
The efficacy of action and safety of use are further strengthened by the excellent pharmacokinetic properties that prevent topically applied chlorhexidine from being absorbed at the systemic level.
Studies carried out and clinical efficacy
CHLOREXIDINE IN THE PREVENTION OF ALVEOLAR OSTEITIS
Med Oral Patol Oral Cir Bucal. 2013 May 31. [Epub ahead of print]
Study demonstrating how the application of Chlorhexidine-based gel at 1% or 0.2% may have the same efficacy in preventing alveolar osteitis after surgical extraction of the third molar.
HYPERSENSITIVITY TO CHLOREXIDINE
JAMA Dermatol. 2013 Feb; 149 (2): 195-9.
Weitz NA, Lauren CT, Weiser JA, LeBoeuf NR, Grossman ME, Biagas K, Garzon MC, Morel KD.
Interesting study that reports the appearance of adverse reactions, and in particular of erosive contact dermatitis, in patients medicated with Chlorhexidine used in order to reduce systemic catheter infections.
CLOREXIDINE AND HOSPITAL INFECTIONS
N Engl J Med. 2013 Feb 7; 368 (6): 533-42. doi: 10.1056 / NEJMoa1113849.
Work that demonstrates how Clorexidine washing can significantly reduce the risk and incidence of infections acquired in the community, and in particular of infections sustained by multi-resistant microorganisms in a hospital environment
Method of use and dosage
LENIL ®
Topical cream for 1 g of Chlorhexidine dihydrochloride per 100 g of product.
Generally we recommend applying the correct amount of cream to injured skin once or more times a day, gently massaging the region.
It is important to avoid contact of the cream with the eyes and mucous membranes.
Warnings LENIL ® Chlorhexidine
The use of LENIL ® is exclusively for topical use, therefore it is recommended to be very careful in its use, taking care to avoid direct contact with eyes and mucous membranes as well as ingestion, the consequent of which could be clinically relevant.
In order to reduce the appearance of sensitization phenomena it would be advisable to avoid the use of LENIL ® for prolonged periods of time, also avoiding direct exposure to ultraviolet rays after application of the product, given the photosensitizing capacity of Chlorhexidine.
Keep the product out of the reach of children
PREGNANCY AND BREASTFEEDING
LENIL ® can be used according to the appropriate indications even during pregnancy and in the subsequent period of breastfeeding.
In any case, it would be advisable to consult your gynecologist before taking this medicine.
Interactions
It is recommended to avoid the simultaneous use of other antiseptics or detergents.
Contraindications LENIL ® Chlorhexidine
The use of LENIL ® is contraindicated in patients who are hypersensitive to the active substance or to one of its excipients.
Undesirable effects - Side effects
The use of LENIL ®, especially when continued for a long time, could determine the appearance of local side effects such as redness, burning and hives.
Note
LENIL ® is a non-prescription drug.
