ZMA HP - EAS

About ZMA HP - EAS

ZMA HP - EAS

Food supplement based on zinc, magnesium and vitamin B6 with N-acetyl cysteine

FORMAT

Pack of 120 tablets

COMPOSITION

Zinc monomethionine

Zinc / Magnesium aspartate

Vitamin B6 - pyridoxine HCl

Dibasic calcium phosphate

Ascorbic acid (Vitamin C)

N-acetyl L-cysteine

DL - alpha tocopherol acetate (Vitamin E)

Stabilizer: microcrystalline cellulose

Anti-caking agents: magnesium stearate and silicon dioxide

Dyes: E171, E172, E555

For three tablets: Magnesium - 450 mg; Zinc - 22.5 mg; Vitamin B6 - 3mg; Vitamin C - 120 mg; Vitamin E - 20 mg; N-acetyl l-cysteine ​​- 200 mg

Product Features ZMA HP - EAS

ZMA - born as a product able to increase the secretion of anabolic hormones and help the muscle growth phase. The patented form combines two important trace elements, such as zinc and magnesium in the most bioavailable forms, with vitamin B6. The intent of this integrator is to replicate and enhance the effects demonstrated for the individual elements:

1. Zinc : trace element involved in the protection from oxidative damage, in the modulation of hormonal function, in the regulation of cell survival and in several other reactions; also seems to play an important role in physical activity. Several studies have shown that the urinary excretion of this element is significantly increased following intense physical exercise, accompanied by an important decrease in muscular ergogenic abilities. At the same time, it seems that supplementation with 3 mg / kg / day of zinc can, in these cases, support muscle growth, saving the loss of testosterone and other hormones.

The most bioavailable form is that associated with methionine, which is found in products of animal origin.

2. Magnesium: central trace element in the maintenance of organic homeostasis. In fact, it is part of more than 300 reactions, participating in both carbohydrate catabolism, necessary to support muscular energy capacities, and in the anabolic phase, allowing the synthesis of various macromolecules, as well as the structural and functional one. Magnesium also guarantees the correct deposition of the bone matrix and regulates the excitatory and contractile abilities of the muscles.

As with zinc, several studies have shown that the need for magnesium can increase by 10/20% in athletes, given the amount eliminated through the urine following exercise, and how its deficiency can be responsible for an increase in the oxidative damage induced by intense physical activity, an immunodepression condition and a reduction in contractile efficacy. At the same time, its supplementation has been shown to improve aerobic capacity (increasing hemoglobin levels), metabolic-energetic (improving carbohydrate oxidation and reducing lactate formation), and anabolic (increasing testosterone levels).

3. Vitamin B6: introduced in the form of pyridoxine, it undergoes a series of enzymatic transformations, mainly in the liver, which activate it in the form of pyridoxal phosphate. Distributed to various tissues, it will become a coenzyme in various biological ways:

Glucose metabolism: gluconeogenesis and glycogenolysis;

Neurotransmitter synthesis: is part of the synthesis of serotonin;

Maintenance of erythrocyte function: coenzyme is included in the EME group synthesis;

Control of hormonal activity;

Nucleic acid synthesis; .

LARNs suggest the intake of 1.1 mg of vitamin B6 for women and 1.5 mg for men, which can be easily satisfied with a balanced diet containing products of animal origin.

Rationale - ZMA HP - EAS

The goal for which this supplement was born was achieved exclusively in an unpublished study, in which an increase was recorded in some anabolic hormones such as testosterone and IGF-1, but readily denied by subsequent studies, which reproduced the same conditions, on a larger sample of athletes, could not describe any benefit.

The inability of the ZMA to replicate at least the results obtained from the separate administration of the individual elements, could be deduced from a published study that shows how the administration of zinc, even at high levels, can interfere with that of magnesium and deregulate the ratio of magnesium absorbed and excreted magnesium.

N-Acetyl L Cysteine: acetylated form of cysteine. The acetylation of this amino acid sulfur significantly improves its pharmacokinetic properties, facilitating intestinal absorption and reducing the competitiveness that is achieved instead for the "food" form. Cysteine ​​is the limiting amino acid in the synthesis of a very important tripeptide, known as glutathione, which is fundamental in counteracting the harmful action of oxidizing substances. Physical exercise, also aerobic, is responsible for the production of reactive oxygen species, which could easily react with cellular structures, damaging them and seriously compromising their functionality. The NAC has been shown to be effective in increasing glutathione levels, and in combating, in synergy with other antioxidants, the oxidative damage induced by intense physical exercise.

Vitamin C - water-soluble vitamin, very abundant in nature, present mainly in products of vegetable origin. Absorbed in the intestine, vitamin C is found in a labile form in the plasma and in a stable form in the tissues, whose quantity inevitably suffers from the blood level.

Its biological activity is expressed as:

- powerful antioxidant, through the regeneration of vitamin E;

- enzymatic cofactor in hydroxylation processes, important for example for the synthesis of collagen, catecholamines and numerous other hormones;

- reducing intestinal iron, with consequent increase in absorption levels;

- reducing folic acid in its coenzymatic forms.

As already mentioned for the NAC, particularly important is the ability of vitamin C, especially when combined with other antioxidants, to counteract the oxidative damage induced by intense physical exercise. This has an immediate effect on the perfromance, and in the long run on the potential recovery of the organism, and in particular of the muscle, which is the tissue most affected by this process.

Its daily requirement is estimated at around 60-90mg, but already at only 10mg, it is able to prevent scurvy, a disease derived from vitamin C deficiency.

Vitamin E: introduced into the body through the diet (mainly through cold-pressed oils and oil seeds), being a fat-soluble vitamin, it is effectively absorbed in the intestine with the help of bile salts. Through the circulatory stream, bound to lipoproteins, vitamin E is carried to the liver and subsequently sorted to the various tissues. The main biological role of this vitamin is antioxidant, reducing the levels of oxidation of polyunsaturated fatty acids, regenerating other antioxidant vitamins such as A and C, and at the same time modulating the activity of cyclooxygenase and lipoxygenase, thus reducing levels of prostanoids responsible for platelet aggregation and associated atherosclerotic disorders. As one can easily imagine, the powerful antioxidant role of vitamin E represents a valuable ally in sports practice, saving the muscle from oxidative damage induced by intense exercise, and supporting not only the performance, but above all the subsequent recovery phase. This vitamin has proven effective in protecting various competitive athletes at very different dosages, which can far exceed those recommended by LARNs.

In the supplementary protocols for athletes we describe dosages around 300 mg / day and above.

The deficiency states in healthy subjects are very rare, while in pathological conditions they are generally associated with neurological deficits.

Even the toxic effects seem to be of little importance; exceeded 2000 mg / day, intestinal problems become evident

Recommended use by company - ZMA HP - EAS

Take 4 tablets before bedtime.

How to use in sports - ZMA HP - EAS

It is very complex to suggest an alternative dosage to that indicated by the manufacturer, as there are no studies in the literature that associate the various products indicated above with one another.

However, if the dosage of the ZMA seems to approach the one used in the only study that reports some advantages related to its use, it seems rather far away that of the NAC, whose antioxidant properties are performed at dosages equal to higher than 600mg.

The combination of these various elements makes the timing of recruitment, which would be preferable on an empty stomach for NAC and ZMA, on a full stomach instead of vitamin E, rather complex and contradictory. Also for this reason, it remains difficult to define an integrative protocol .

ZMA HP - EAS side effects

Zinc: high amounts of zinc introduced are responsible for abdominal pain, diarrhea, nausea and vomiting. Chronic zinc administration (60 mg / day total) is associated with copper deficiency.

Magnesium: high amounts of magnesium are responsible for profuse diarrhea. The increase in serum magnesium levels is instead associated with hypotension, confusion, heart rhythm disorders, deterioration of renal function, fatigue, difficulty in breathing, and even cardiac arrest. The dose of safe supplementation appears to be 350 mg / day.

Vitamin B6: chronic administration can be responsible for damage to the nervous system and neuropathies of various levels already at doses higher than 200mg / day.

NAC: no particular side effects of oral supplementation with NAC have been recorded even for prolonged periods. However, strict medical supervision is required, in the case of asthmatic individuals, with diseases of the respiratory tract or with diseases of the gastrointestinal tract.

Vitamin C: side effects characterized by gastro intestinal disorders due to the acidity of this vitamin, are recorded for pharmacological dosages, that is above 10 gr / day.

Vitamin E: the tolerated daily dose appears to be that of 1 g / day (1500 IU), beyond which gastro-intestinal problems may occur .

HP ZMA interactions - EAS

Zinc: in addition to interfering with other trace elements such as copper, it could reduce the absorption of some antibiotics such as tetracyclines, reducing their effectiveness.

Magnesium: may interfere with some antibiotics, tranquilizers and oral anticoagulants, reducing their effectiveness.

Precautions for using ZMA HP - EAS

The product is contraindicated in cases of renal or hepatic disease, cardiovascular disease and / or hypertension, during pregnancy, during lactation and under 14 years.

This article, elaborated on the critical re-reading of scientific articles, university texts and common practice, is for informational purposes only and is therefore not a medical prescription. It is therefore always necessary to consult your doctor, nutritionist or pharmacist before starting to use any kind of supplement . Learn more about the critical analysis of ZMA HP - EAS.