ADVANTAN ® Methylprednisolone

ADVANTAN ® is a drug based on Methylprednisolone aceponate

THERAPEUTIC GROUP: Non-associated corticosteroids, dermatological preparations

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Directions ADVANTAN ® Methylprednisolone

ADVANTAN ® is indicated for the treatment of various inflammatory skin diseases such as atopic dermatitis, neurodermatitis and eczema.

Mechanism of action ADVANTAN ® Methylprednisolone

ADVANTAN ® is a drug based on Methylprednisolone aceoponate, a corticosteroid molecule with halogenated residues able to optimize the process of skin penetration, making topical therapy particularly effective.

Used through the skin in fact the active principle easily penetrates the skin, generating a secondary metabolite endowed with biological activity, capable of interacting with specific nuclear receptors by modulating the gene expression of the cells involved and inducing the expression of molecules such as Lipocortin, in able to block the process of synthesis of inflammatory mediators upstream, reducing the activity of the enzyme Phospholpiasis A2.

The reduced expression of inflammatory mediators causes a significant reduction in the inflammatory insult, with a relatively rapid remission of the complained symptomatology.

Studies carried out and clinical efficacy

METHYLPREDNISOLONE IN THE TREATMENT OF LICHEN AUREUS

Australas J Dermatol. 2011 May; 52 (2): e15-8. doi: 10.1111 / j.1440-0960.2010.00655.x. Epub 2010 May 12.

Clinical study that reports the effectiveness of Methylprednisolone in the treatment of Lichen Aureus in two patients aged 9 and 23 years, without the appearance of clinically relevant adverse reactions.

EFFECTIVENESS OF METHYLPREDNISOLONE IN THE TREATMENT OF ATOPIC ECZEMA

J Eur Acad Dermatol Venereol. 2012 Nov; 26 Suppl 6: 14-5. doi: 10.1111 / j.1468-3083.2012.04712.x.

Work that demonstrates the effectiveness of ADVANTAN in reducing the symptoms related to eczema in a small patient nine months, significantly improving the quality of his sleep. Everything was done without the appearance of particular side effects.

contact dermatitis TO METHYLPREDNISOLONE

G Ital Dermatol Venereol. 2013 Jun; 148 (3): 307-8.

Case report reporting the appearance of contact dermatitis in a patient receiving methylprednisolone aceponate. These evidences underline the importance of adequately assessing all the potential contraindications to the use of such drugs.

Method of use and dosage

ADVANTAN ®

Topical cream, hydrophobic cream, ointment and 0.1% Methylprednisolone aceponate skin solution.

The choice of the pharmaceutical format and the therapeutic scheme is left to the competent doctor after having carefully evaluated the general condition of the patient and the severity of the relative clinical picture.

Generally, it is advisable to apply the appropriate amount of medicine directly to the lesion once a day, taking care to gently massage the same area.

ADVANTAN ® in cream is generally used in the treatment of secreting eczematous forms and skin areas subject to maceration; ADVANTAN ® in hydrophobic cream is indicated in the treatment of not too dry and not too secreting lesions; ADVANTAN ® ointment is generally preferred in the treatment of dry inflammatory lesions; ADVANTAN ® cutaneous solution is used in the treatment of dermatoses of the scalp and cutaneous regions covered by hair.

Warnings ADVANTAN ® Methylprednisolone

The use of ADVANTAN ® should necessarily be preceded by an appropriate medical consultation to evaluate both the origin of the lesions and the appropriate prescription.

Topical use of corticosteroids requires compliance with different sanitary regulations useful for limiting the spread of the drug in the environment and the resulting side effects.

The patient receiving ADVANTAN ® should therefore:

thoroughly clean the area to be treated before each application;
clean hands thoroughly after each application;
avoid contact of the drug with eyes and mucous membranes;
avoid the application of the product on particularly large and obviously damaged skin regions;
avoid prolonged use of the drug;
keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

The use of ADVANTAN ® during pregnancy and in the subsequent period of breastfeeding is generally contraindicated given the potential side effects of corticosteroids for the health of the fetus and infant, despite the low systemic absorption of the active ingredient.

Interactions

The low systemic absorption of the active principle significantly limits the risk of clinically relevant drug interactions.

Contraindications ADVANTAN ® Methylprednisolone

The use of ADVANTAN ® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients and in patients suffering from serious bacterial and viral infections such as tuberculous, lactic and vital processes, rosacea or perioral dermatitis.

Undesirable effects - Side effects

The use of ADVANTAN ®, especially when prolonged over time or carried out on large areas of the skin, could expose the patient to the risk of local reactions such as itching, burning, erythema, dry skin, folliculitis, skin discoloration, atrophies etc.

Fortunately, systemic or allergic adverse reactions are rarer.