OTALGAN ® Fenazone and Procaine

OTALGAN ® is a drug based on Fenazone and Procaine.

THERAPEUTIC GROUP: Other otologs.

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Directions OTALGAN ® Fenazone and Procaine

OTALGAN ® is indicated in the treatment of painful manifestations of the ear.

Mechanism of action OTALGAN ® Fenazone and Procaine

The pain-relieving and anti-inflammatory properties of OTALGAN ® are evidently associated with its active ingredients, with different but complementary therapeutic activities.

More precisely, Fenazone ® is an active ingredient with anti-inflammatory and antipyretic activity, probably due to its ability to inhibit the synthesis of inflammatory mediators such as prostaglandins, prostacyclins and thromboxanes by blocking the activity of cyclooxygenase enzymes.

Procaine, on the other hand, is a typical local anesthetic with a short duration of action, which by blocking the opening of the sodium channels of the excitable cells, including those involved in the transmission of pain, inhibits depolarization and the consequent transmission of the pain signal.

The typical use of the aforementioned active ingredients, limiting their systemic absorption, allows to effectively control all the potential side effects.

Studies carried out and clinical efficacy

CLINICAL EFFECTIVENESS OF OTALGAN

Arzneimittelforschung. 2009; 59 (10): 504-12. doi: 10.1055 / s-0031-1296434.

Extensive German clinical trial confirming the clinical efficacy of OTALGAN in improving pain and inflammation of the ear canal in over 400 pediatric patients.

FENAZONE PHARMACOGENOMICS

Bull Exp Biol Med. 2011 Aug; 151 (4): 445-8.

Interesting genomic drug study that demonstrates how the pharmacokinetics of active ingredients such as Fenazone can vary significantly from patient to patient based on their gene structure, referring mainly to that of cytochromial enzymes.

EFFECTIVENESS AND SAFETY OF EAR DROPS WITH BASEI DI FENAZONE

Ann Pediatr (Paris). 1993 Sep; 40 (7): 481-4.

Yet another study that demonstrates the efficacy and excellent tolerability of ear drops based on anti-inflammatories such as Fenazone and anesthetics such as lidocaine in the treatment of congestive otitis in pediatric patients.

Method of use and dosage

OTALGAN ®

Otological solution of 5 g of Phenazone and 1 g of Procaine hydrochloride per 100 g of product.

The definition of the dosing schedule is the responsibility of the doctor following a careful evaluation of the patient's clinical conditions.

Generally, in adults, 2-4 instillations per day of 5-8 drops are recommended; dosages should obviously be reviewed in pediatric patients.

Warnings OTALGAN ® Fenazone and Procaine

As with any product intended for otological use, it is recommended to evaluate in advance the integrity of the tympanic membrane in order to avoid the onset of unpleasant side effects, taking care also to warm the vial before use.

Prolonged use of OTALGAN ® over time could lead to the onset of sometimes annoying sensitization phenomena.

PREGNANCY AND BREASTFEEDING

The use of OTALGAN ® is compatible with pregnancy and the subsequent period of breastfeeding, provided that such therapy takes place under the supervision of your doctor.