DUAC ® Benzoyl Peroxide + Clindamycin

DUAC® is a drug based on Benzoyl Peroxide + Clindamycin phosphate

THERAPEUTIC GROUP: Anti-acne preparations for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications DUAC ® Benzoyl peroxide + Clindamycin

DUAC® is used in the treatment of moderate and severe vulgar acne especially in the presence of inflammatory lesions.

Mechanism of action DUAC ® Benzoyl peroxide + Clindamycin

DUAC® is a medicinal specialty that combines the therapeutic activity of two different active ingredients such as Benzoyl Peroxide and Clindamycin, thus enhancing therapeutic and antiacneic potential.

More precisely, benzoyl peroxide performs both an antiseptic action directed towards Propionibacterium acnes and a modest exfoliating and keratolytic action, Clindamycin on the other hand, by inhibiting the ribosomal subunit 23 S, blocks protein synthesis and therefore the proliferation of Gram positive bacteria among the such as precisely P. acnes, at the same time carrying out a sensitive sebostatic action, important in reducing sebaceous hypersecretion typical of acneic pathology.

The combination of these two different active ingredients proved to be decidedly more effective than the monotherapies, in regulating sebum secretion and inhibiting bacterial proliferation, also controlling the amount of inflammatory lesions.

Studies carried out and clinical efficacy

CLINICAL EFFECTIVENESS OF GEL WITH CLINDAMYCIN BASIS

Int J Dermatol. 2013 Jun 20. doi: 10.1111 / ijd.12002. [Epub ahead of print]

Clinical trial that demonstrates how Clindamycin-based gels can be very effective in treating acne vulgaris, guaranteeing prompt remission of even inflamed acne lesions.

CLINDAMYCIN / BENZOIC ACICO AND INNOVATIVE THERAPIES COMPARED

J Drugs Dermatol. 2013 Mar; 12 (3): 266-9.

Work that reaffirms the efficacy and clinical safety of the associated therapy between Benzoic acid and Clindamycin in the treatment of acne vulgaris, resulting as effective as innovative therapies.

CLINDAMYCIN AND BENZOYL PEROXIDE IN ACNE VOLGARE

Cutis. 2013 Feb; 91 (2): 99-104.

A clinical trial that demonstrates how effective and safe treatment of vulgar acne with Clindamycin plus benzoyl peroxide is effective and safe when applied for at least 12 weeks.

Method of use and dosage

DUAC®

Topical gel with 1 Clindamycin and 5% benzoyl peroxide.

It is generally recommended to apply the correct amount of gel to the skin region affected by the inflammatory event once a day, preferably in the evening, gently massaging the area in order to optimize the absorption of the medicine.

The duration or possible corrections of the standard therapy should be defined by the competent doctor.

Warnings DUAC ® Benzoyl Peroxide + Clindamycin

The patient being treated with DUAC® should comply with some important rules in order to maintain the therapeutic efficacy of the drug, avoiding the onset of unpleasant side effects.

More precisely it should:

thoroughly clean the area to be treated before applying DUAC®;
clean hands after using the medicine;
avoid ingestion and contact of the drug with eyes and mucous membranes;
avoid the use of the medicine in case of contextual dermatological pathologies;
avoid exposure of the treated area to sunlight.

It is also recommended to keep the medicine in a cool and dry place, out of reach of children.

PREGNANCY AND BREASTFEEDING

Given the absence of studies able to fully characterize the absorption and safety profile of the active ingredients contained in DUAC® for the health of the fetus and infant, it is preferable to avoid the use of the drug during pregnancy and in the following period breastfeeding.

Interactions

In order to preserve the safety of the treatment with DUAC® it would be preferable to avoid the simultaneous intake of cortisone and topical drugs, especially exfoliants or antacnees.

Contraindications DUAC ® Benzoyl peroxide + Clindamycin

The use of DUAC® is contraindicated in patients who are hypersensitive to the active ingredient or to one of its excipients and in patients suffering from dermatological diseases.

Undesirable effects - Side effects

The use of DUAC®, especially if continued over time or carried out on particularly sensitive patients, could lead to the appearance of local adverse reactions such as irritation, scaling, depigmentation, redness and burning.

Only rarely have adverse reactions worthy of clinical note been observed and such as to require the suspension of treatment.