AMINO-4 complex - ANDERSON

Information on AMINO-4 complex - ANDERSON

AMINO-4 complex - ANDERSON

Food supplement of branched chain amino acids with Arginine alpha keto-glutarate, Zinc monomethionine and vitamin B6

FORMAT

Pack of 60/100/200 tablets

INGREDIENTS: L-Leucine - L-Isoleucine - L-Valine - Arginine alpha keto-glutarate - Stabilizer: microcrystalline cellulose - Anti-caking agents: magnesium stearate, silica dioxide - Zinc monomethionine - Vitamin B6

For 5 tablets: L-leucine 2500 mg - L-valine 1250 mg - L-isoleucine 1250 mg - Arginine alpha keto-glutarate 625 mg - Zinc monomethionine 17 mg - Vitamin B6 2 mg

Branched chain amino acids - essential amino acids involved in numerous reactions and key functions for the human body. Their peculiarity manifests itself with the ability to skip the first gastro-intestinal and liver metabolism, and reach the muscle tissue with excellent bioavailability.

The metabolism of branched amino acids, mainly muscular, is due to the presence of two key enzymes, BCAT and BCKD, which initialize their catabolism and subsequently direct them towards specific products, depending on the physiological and nutritional needs of the organism. Among the most important functions of branched chain amino acids there is certainly the plastic one, since they significantly influence the protein structure and its function, especially of transmembrane proteins fundamental in regulating cellular functionality. To the plastic and reconstructive function towards muscle myofibrils, the metabolic role that guarantees:

1. Energy production through oxidation;
2. Glucose synthesis by gluconeogenesis and alanine glucose cycle, and its insulin response;
3. Increase in plasma glutamine levels, fundamental both for detoxification and maintenance of the athlete's immune defenses;
4. Reduction in plasma levels of aromatic amino acids, with a consequent decrease in the synthesis of associated neurotramsettiori.

BCAA in sports practice

The metabolic and plastic effects previously listed are only the means necessary to achieve the athlete's goals. In fact, in sports practice the BCAAs are used in order to:

1. Reduce proteolysis induced by intense physical exercise : branched-chain amino acids, in fact, could provide the energy surplus necessary to delay the onset of muscular amino acid catabolism. Several research groups seem to agree that this effect is possible, also thanks to experimental data that show a clear decrease in markers of tissue damage, such as creatine kinase and lactic dehydrogenase, following intense physical exercise;
2. Reduce the feeling of fatigue : an action that would be achieved through an inhibitory effect on the release of aromatic amino acids on the one hand, and through a competitive effect against tryptophan, in crossing the blood-brain barrier, on the other. This results in a reduction in the synthesis of serotonin, a neurotransmitter involved in the onset of the sensation of fatigue.
3. Improve the body's anabolic abilities: thanks to its ability to stimulate insulin secretion and its modulating action against its intracellular signal, with a significant improvement in protein synthesis. To this effect is added another, still much debated, observed by some research groups, which would be explained by the increase in anabolic hormones, such as testosterone and GH, and with the reduction of the catabolic hormone par excellence: the cortisol.

   To date, however, the most reproducible and therefore most reliable effects are those related to the protective action against muscle tissue (anti-catabolic action) and the ability to reduce the feeling of fatigue. These effects, however, do not correspond to a significant, direct improvement in performance

Arginine alpha keto glutarate: arginine salt consisting of two arginine molecules joined by one of alpha keto glutarate. Arginine is a semi-essential amino acid that needs to be taken through the diet, especially in the event of increased need, which is achieved even after intense physical activity. Arginine is essential in numerous biological reactions, returning:

1. in the urea cycle, facilitating the elimination of waste products deriving from amino acid oxidation;
2. In the gluconeogenic process, supplying the body with glucose in the event of energy deficiency,
3. In the processes of protein synthesis, exercising a plastic function;
4. In the metabolism of nitric oxide of endothelial derivation.

Alpha ketoglutarate is a very important metabolic keto acid; in fact it represents a crossroads between catabolic and anabolic reactions. This molecule re-enters:

1. in the krebs cycle, thus favoring energy production;
2. in the gluconeogenic process, allowing the synthesis of glucose starting from non-carbohydrate sources,
3. in the synthesis of some amino acids such as glutamate, then glutamine, proline and arginine.
4. In improving collagen synthesis;
5. In preserving the protein component in patients with nephropathy and severe malnutrition (still experimental studies).

Arginine and sport: for some time now, various sportsmen have been using this supplement in the hope of obtaining the following results:

1. Increased growth hormone release;
2. Increased lean mass;
3. Better sports performance;
4. Increase in resistive capacity and maximum force.
5. Increased levels of nitric oxide: able to promote vasodilation processes.

The metabolic effect of arginine and alpha ketoglutarate may also be useful in energetically supporting the cell, and in improving the muscle recovery phase by preserving the muscle from proteolysis and increasing protein synthesis

Rational AAKG

The studies in which there is a significant increase in plasma GH levels are somewhat discussed, while the ergogenic capacity appears to be more certain, which translates into an increase in the maximum force peak and in the delay in the onset of anaerobic metabolism.

Zinc monomethionine: the most available form compared to that complexed with phytic acid present in products of vegetable origin, it is absorbed in the intestine and subsequently concentrated in various tissues and in particular in the bones, skin, liver, muscles and hair, where it is part of numerous biological reactions necessary to guarantee the correct process of growth and differentiation, tissue repair, modulation of hormonal activity, regulation of the immune response and protection against oxidative insults. Its requirement, attested between 7 and 10 mg per day, tends to increase significantly following intense physical activity, in which the urinary secretion of this trace element significantly increases, accompanied by a decline in the contractile and energy capacity of the muscle. Furthermore, studies conducted at zinc concentrations equal to 3mg / kg / day, allowed to effectively combat the fall of hormones such as testosteorone and thyroid hormones following intense physical exercise. Despite the potential benefits that derive from a correct supplementation, it is necessary to consider that a surplus of zinc is effectively disposed of through an increase in urinary secretion. Deficiency of this element, albeit rare, can affect some risk groups, resulting in delayed sexual maturation, skin rashes, chronic and profuse diarrhea, asthenia, loss of appetite, immune system deficiency and general malaise.

Vitamin B6: pyridine derivative introduced mainly through foods of animal origin. This vitamin is absorbed at the level of the fast, after dependent ATP hydrolysis, and reaches the liver bound to albumin. Here it is transformed into pyridosamine, then into pyridoxal and then phosphorylated, with consequent activation and storage. From the liver it will then be released in a non-phosphorylated circle, to reach the various tissues where, once rephosphorylated, it will be able to perform its biological role.

1. Increases blood glucose levels: it favors glycogenolysis and gluconegoesis;
2. Ensures correct amino acid oxidation and transamination processes;
3. Promotes the synthesis of neurotransmitters such as serotonin, dopamine, norepinephrine and GABA.
4. Leads the synthesis of the EME group, necessary for hemoglobin to bind oxygen;
5. It allows the synthesis of Niacin, starting from tryptophan;
6. Modulates hormonal action;

Its daily requirement is around 1 / 1.5 mg, but even in this case the cases of deficiency are very rare.

Product features - AMINO-4 complex - ANDERSON

The product in question associates with other branched chain amino acids other important nutrients, such as vitamin B6, zinc and alfachetoglutarate arginine. Interesting and innovative is the association between BCAAs and zinc, which proved effective in a recent study in improving protein metabolism in individuals with liver cirrhosis, while data on sports use are lacking. The synergy with arginine is more tested, able to enhance the anabolic effects in post-work-out . Vitamin B6 should instead ensure better use of BCAAs.

Recommended use by the company - AMINO-4 complex - ANDERSON

Mix a portion of 5g (one heaped teaspoon) in 300-400 ml of water, fruit juice or in your favorite beverage. Take before and / or after training.

Use in sports - AMINO-4 complex - ANDERSON

In order to define an optimal dosage of the product in question, it is necessary to consider effective supplementary protocols for the individual elements.

Therefore, while the 5 tablets provided by the manufacturer can meet the average requirement (83mg / kg / day) of BCAAs for a 70 kg man, they fail to reach significant values ​​for arginine (effective in a range between 2 and 8 mg / day) and for zinc (effective at 3 mg / kg / day).

Added to this is the fact that the dosage of BCAAs should also be calculated based on the nutrition and the nutritional and physio-pathological state of the athlete.

However, the advice on an empty stomach is always valid, dividing the dose into pre and post work out according to the needs of the athlete.

Synergies AMINO-4 complex - ANDERSON

BCAA + Arginine: a study carried out on 8 healthy volunteers shows a significant reduction in phenylalanine levels (muscle proteolysis marker) following physical exercise preceded by integration with 2 g of BCAA and 0.5 g of arginine.

BCAA + Carbohydrates: some studies show a useful synergy to reduce the feeling of fatigue during athletic performance (potential role of BCAAs), and improve performance (energy role of carbohydrates). In the post work out, on the other hand, CAAs seem to improve insulin sensitivity, therefore glycogen resynthesis in the presence of CHO, while high glycemic index carbohydrates, increasing insulin secretion, can both favor the absorption of the same BCAAs and support the anabolic phase

AMINO-4 complex side effects - ANDERSON

The long-term side effects of a diet too rich in proteins or amino acids are well known. Renal damage, dehydration induced by increased urinary secretion, lipidemic alterations and associated pathologies, tissue acidosis and bone demineralization, are just some of the consequences of an unbalanced diet that lasts over time.

Acute BCAA ingestion appears to be well tolerated and free of side effects, even when concentrations rise to 450mg per kilogram of body mass.

Precautions for use AMINO-4 complex - ANDERSON

The product is contraindicated in cases of renal or hepatic disease, cardiovascular disease and / or hypertension, during pregnancy, during lactation, under 12 years and for adolescents not yet trained.

In the event of prolonged use (over 6/8 weeks), medical advice is required.

This article, elaborated on the critical re-reading of scientific articles, university texts and common practice, is for informational purposes only and is therefore not a medical prescription. It is therefore always necessary to consult your doctor, nutritionist or pharmacist before starting to use any kind of supplement . Further information on the critical analysis of AMINO-4 complex - ANDERSON.

BIBLIOGRAPHY

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