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VALPINAX ® Ottatropin methyl bromide + diazepam

VALPINAX ® is a drug based on octatropin methyl bromide + diazepam

THERAPEUTIC GROUP: spasmolytics.

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Indications VALPINAX ® Ottatropin methyl bromide + diazepam

VALPINAX ® is indicated for the symptomatic treatment of painful spastic manifestations of the gastro-intestinal tract, especially if determined by an anxious component.

VALPINAX ® is also indicated for psychomotor agitation, delirium tremens, withdrawal symptoms and irritable bowel syndrome.

Mechanism of action VALPINAX ® Ottatropin methyl bromide + diazepam

The particular therapeutic indications of VALPINAX ® are due to the combination of two active ingredients that are particularly effective in contrasting both the spastic contraction of the gastro-intestinal muscles and the anxious disorders of the emotional sphere.

More precisely:

  1. Otatropin methyl bromide, a derivative of atropine, acts selectively at the level of smooth muscle cells in the gastrointestinal tract, competing with acetylcholine for binding to muscarinic receptors, and thus reducing the excitation state and subsequent contraction of these cells.
  2. Diazepam, belonging to the benzodiazepine group, is able to act at the level of the central nervous system, improving the affinity of some nerve receptors to GABA. This neurotransmitter, with marked inhibitory and hyperpolarizing activities, is able to guarantee a sedative and anxiolytic effect.

This combination guarantees an integrated therapeutic approach for all those spastic-painful manifestations of the gastrointestinal tract linked to disorders of the emotional sphere.

Studies carried out and clinical efficacy

1 VALPINAX AND IRRITABLE COLONY SYNDROME

This Italian study, conducted on 186 patients between 18 and 65 years, suffering from irritable bowel syndrome, shows how taking VALPINAX at therapeutic doses can determine a significant improvement in the painful symptoms of the gastrointestinal tract. Side reactions, of weak entity, were recorded in 15% of patients undergoing therapy.

2. BUTYLBROMURO OTTATROPINE IN THE TREATMENT OF DUODENAL ULCER

Italian study conducted on 40 patients suffering from duodenal ulcers (confirmed by endoscopy), which highlights the particular efficacy of octatropin methyl bromide in reducing ulcer-induced pain.

3. BENZODIAZEPINE AND IRRITABLE COLONY SYNDROME

This important metanalysis study shows how the association of benzodiazepines, such as diazepam, with classical anticholinergics, with muscle relaxant activity, can guarantee a complete therapeutic approach to irritable bowel syndrome, improving not only intestinal pain and prominent diarrhea, but also the anxious state partly responsible for the pain symptoms.

Method of use and dosage

VALPINAX ® tablets (ottatropin methylbromide 40mg + diazepam 2.5mg): 1-2 tablets per day are recommended.

VALPINAX ® 4% oral drops: we recommend taking 25/30 drops twice a day.

The dosage for elderly people must necessarily be established by your doctor.

Warnings VALPINAX ® Ottatropin methyl bromide + diazepam

The presence of psychotropic substances in VALPINAX ® could determine:

  1. onset of unpredictable individual reactions following the contextual consumption of alcohol;
  2. dependence and relative withdrawal syndrome with psycho-physical symptoms, following prolonged administration and subsequent interruption;
  3. changes in liver function and blood chemistry values;

For this reason it is always necessary to take VALPINAX ® under strict medical supervision, paying particular attention to elderly, debilitated patients suffering from hepatic and renal dysfunction, cardiovascular insufficiency and disorders of the nervous system.

The presence of anticholinergics in VALPINAX ® could determine:

  1. episodes of gastro-esophageal reflux, particularly intense for those suffering chronically of this condition;
  2. worsening of respiratory capacity following reduction of bronchial secretions;
  3. the onset of tremor, irritability and agitation, with rare seizures in particular predisposed subjects, when taken at high doses;
  4. cause addiction and dependence.

Consequently, it is necessary to use VALPINAX ® with caution, and under strict medical supervision, in the case of disorders of the autonomic nervous system, of liver and / or renal diseases, of chronic obstructive inflammatory diseases of the respiratory system, of hyperthyroidism, of coronary heart disease, in congestive heart failure, in cardiac arrhythmias, in hypertension and, especially in children, in the presence of hyperpyrexia.

The simultaneous presence of anticholinergics and benzodiazepines, could significantly affect the ability to concentrate and pay attention, making driving or the use of particular instruments and machinery unpredictable and dangerous.

PREGNANCY AND BREASTFEEDING

We do not recommend the use of VALPINAX ® during the first trimester of pregnancy, while in the following period medical advice would be essential.

Interactions VALPINAX ® Ottatropin methyl bromide + diazepam

VALPINAX ® due to the presence of anticholinergics, can interact with:

  1. Tricyclic antidepressants, accentuating their effect.
  2. Anticholinergics of various kinds, enhancing their effects;
  3. Antihistamines, capable of interfering with the normal functioning of the drug;
  4. Parasipathomimetic agents, which cancel the therapeutic effect.

The sedative effects induced by diazepam can be enhanced by neuroleptics, tranquilizers, antidepressants, hypnotics, analgesics, anesthetics and antihistamines.

Contraindications VALPINAX ® Ottatropin methyl bromide + diazepam

VALPINAX ® is contraindicated in debilitated, elderly patients with prostatic hypertrophy, glaucoma, urinary retention syndromes or intestinal obstruction (pyloric stenosis), paralytic ileus, ulcerative colitis, megacolon, reflux oesophagitis, myasthenia gravis, cardiovascular diseases, ulcerative colitis, hypersensitivity towards one of the components of the product.

Undesirable effects VALPINAX ® Ottatropin methyl bromide + diazepam

Unbalanced doses of VALPINAX ® can cause side effects due to an exasperating sedating effect such as:

  1. Drowsiness
  2. Sense of fatigue and muscle weakness
  3. Dizziness.

More rare are symptoms such as:

  1. Depression
  2. Ataxia
  3. Confusion
  4. Hypotension
  5. Urinary incontinence
  6. tremor
  7. rashes.

The presence of anticholinergics in VALPINAX ® could also cause dryness of the oral cavity, accommodation disturbances, photophobia, gastro-intestinal disorders, headaches.

Note

Notes: the VALPINAX ® Ottatropin methylbromide + diazepam drug is available only upon presentation of a prescription.

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