LOCETAR ® Amorolfine

LOCETAR ® is a drug based on amorolfine hydrochloride

THERAPEUTIC GROUP: Antimycotics for topical use

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Directions LOCETAR ® Amorolfine

LOCETAR ® is indicated for the treatment of onychomycosis caused by yeasts, molds and dermatophytes sensitive to Amorolfine.

Mechanism of action LOCETAR ® Amorolfine

LOCETAR ® is a recently introduced drug based on amorolfine, an active ingredient with a significant fungicidal and fungistatic activity determined by impairment of the normal structure of the plasma membrane.

Applied topically, Amorolfine easily penetrates the plasma membrane concentrating at the cytoplasmic level where it inhibits various enzymes involved in the biosynthesis of Ergosterol, a key sterol for the maintenance of the structural and functional organization of the fungal membrane, whose absence induces a serious alteration of the vital abilities of the dermatophyte.

The reduced capacity of exchange on the one hand and the accumulation of toxic catabolites seriously compromise both the replicative capacity of the fungus and the normal vitality, thus guaranteeing a prompt improvement of the symptomatology.

Studies carried out and clinical efficacy

AMOROLFINA IN THE TREATMENT OF TIGNA

Indian J Dermatol. 2011 Nov; 56 (6): 657-62. doi: 10.4103 / 0019-5154.91823.

Clinical trial that demonstrates how the use for eight weeks of Amorolfine based skin creams can be effective in the treatment of bodily ringworm, guaranteeing in a short time a clear improvement of the clinical picture.

UNGUEAL PENETRATION OF AMOROLFINA

J Eur Acad Dermatol Venereol. 2013 Feb; 27 (2): e153-8. doi: 10.1111 / j.1468-3083.2012.04529.x. Epub 2012 Mar 26.

Pharmacokinetic study that evaluates the ability of penetration of Amorolfine in the various nail layers, describing its good permeability even if lower than new cyclopirox delivery systems.

AMOROLFIN contact dermatitis

Actas Dermosifiliogr. 2010 Apr; 101 (3): 281-3.

Case report that reports the appearance of allergic contact dermatitis following the use of Amorolfine-based nail polishes. These evidences confirm the importance of medical supervision during treatment with these drugs.

Method of use and dosage

LOCETAR ®

5% Amorolfine nail polish.

Unless otherwise prescribed by a doctor, it is generally advisable to apply the appropriate quantity of nail polish directly on the region affected by the infectious process once or twice a week, taking care previously to file the nail eliminating all hyperkeratinization residues.

Warnings LOCETAR ® Amorolfine

Treatment with LOCETAR ® should be preceded by a careful medical examination aimed at clarifying the origin of the nail lesion and the consequent prescription appropriateness of the drug.

The patient on Amorolfine should be careful to avoid contact of the medicine with mucous membranes and eyes, to avoid the simultaneous use of enamels or cosmetics during therapy, and to avoid using the same instruments for healthy and sick nails.

Keep the medicine out of the reach of children.

PREGNANCY AND BREASTFEEDING

Considering the very low systemic absorption that would result from the use of LOCETAR ® topically, the use of the medicine during pregnancy and during breastfeeding could be realized, only in cases of real need, under the strict supervision of your doctor.

Interactions

Pharmacological interactions worthy of note are not known at the moment, although it would be preferable to avoid the simultaneous use of other nail cosmetics.