DIFLUCAN GEL ® Fluconazole

DIFLUCAN GEL ® is a Fluconazole based drug

THERAPEUTIC GROUP: Antifungals for cutaneous use - triazole derivatives

IndicationsAction mechanismStudies and clinical effectiveness Usage and dosage instructionsWarnings Pregnancy and lactationInteractionsContraindicationsUndesirable effects

Directions DIFLUCAN GEL ® Fluconazole

DIFLUCAN GEL ® is used in the treatment of cutaneous mycoses sustained by yeasts, fungi and dermatophytes such as Tinea spp and Candida.

Mechanism of action DIFLUCAN GEL ® Fluconazole

DIFLUCAN GEL ® is a drug based on Fluconazole, an active ingredient with antifungal activity, generally taken orally or parenterally, but which in this case is used topically.

More precisely applied to the area affected by the infectious process, the active principle easily penetrates through the plasma membrane concentrating in the fungal cell and inhibiting enzymes involved in the synthesis of ergosterol, a fundamental element for its structure.

This activity also determines the accumulation of numerous metabolites capable of interfering with normal membrane activity, compromising the viability of the cell itself.

All this then translates into a prompt regression of the symptomatology due to the inhibition of the growth and vitality of the pathogenic elements.

The effectiveness of the treatment is also supported by the excellent pharmacokinetic properties that prevent the active ingredient from reaching blood concentrations with a pharmacological effect.

Studies carried out and clinical efficacy

FLUCONAZOLO: new delivery systems

AAPS PharmSciTech. 2002; 3 (4): E35.

Pharmacokinetic studies that test new Fluconazole delivery systems for topical use, in order to optimize the clinical effectiveness of the treatment, maintaining safe and easy administration.

THE USE OF FLUCONAZOLE IN OPHTHALMOLOGICAL DISORDERS

Curr Eye Res. 2003 Feb; 26 (2): 113-7.

Work demonstrating that treatment with both oral and topical Fluconazole is effective in the treatment of Aspergillus-induced keratitis.

However, it is useful to remember that these results are still in the experimental phase and conducted on animal models.

THE FLUCONAZOLE IN CHEMIOPROPHYLAXIS OF FUNGAL INFECTIONS IN PREMATURE

J Paediatr Child Health. 2012 Sep; 48 (9): 846-51.

Interesting study that tests the effectiveness of Fluconazole in preventing invasive fungal infections in preterm infants weighing less than 1.5 kg and therefore potentially at risk.

Method of use and dosage

DIFLUCAN GEL ®

Fluconazole 0.5% cutaneous gel.

Generally the application of the correct quantity of gel on the skin region affected by the infectious process once a day for 1-3 weeks is sufficient to guarantee a remission of the symptoms.

If the results are late, it would be advisable to consult your doctor with whom to evaluate the possibility of prolonging the therapy.

Warnings DIFLUCAN GEL ® Fluconazole

The use of DIFLUCAN GEL ® should occur after an adequate medical consultation useful to characterize the pathology in progress.

In order to avoid contact of the product with the mucous membranes, thorough cleaning of the hands is recommended.

Given the photosensitizing power of Fluconazole it would be advisable to avoid direct exposure to the sun following the use of DIFLUCAN GEL ®, in order to reduce the risk of burns.

It is recommended to store the drug in a cool, dry place out of reach of children

PREGNANCY AND BREASTFEEDING

The absence of clinical trials able to characterize the safety profile of the drug for the health of the fetus and the infant, extends the contraindications to the use of the drug also to the pregnancy and to the following period of breastfeeding.

Interactions

The low systemic absorption of the active principle minimizes the risk of potential pharmacologically relevant interactions, thus making DIFLUCAN GEL ® therapy generally safe.

Contraindications DIFLUCAN GEL ® Fluconazole

DIFLUCAN GEL ® is generally contraindicated during pregnancy and lactation and in all patients with known hypersensitivity to the active ingredient or to one of its excipients in addition to structurally related molecules.