HMB - 1000 Maximixe

Information on HMB - 1000 Maximixe

HMB - 1000 MAXIMIZE

Food supplement based on hydroxy beta methyl butyrate

FORMAT

90 cps bottle

COMPOSITION

Hydroxy beta methylbutyrate (HMB): salified with calcium

Capsule: edible gelatin

Anti-caking agents: magnesium stearate

E17 coloring agent

One capsule contains: Hydroxybetyl methyl butyrate 1000 mg

Product features HMB - 1000 Maximixe

Hydroxy beta methyl butyrate - molecule derived from the transamination process of one of the three branched chain amino acids. In fact, a keto acid, the alpha ketoisocaproate, which is the direct precursor of the hydroxy methyl butyrate is generated from leucine by transamination. A balanced diet, in a 70 kg man, can provide about 200/400 mg of HMB a day, a decidedly lower quantity than that commonly used in sports supplementation (3gr), to which ergogenic effects are registered. The pharmacokinetic and pharmacodynamic properties of this molecule are not yet fully characterized, but from the studies present in the literature a potential ability to reduce protein degradation and increase of synthesis is shown; and this is precisely the much sought after effect in sports integration. The supposed biological mechanisms, at the base of this effect, have yet to be demonstrated, but the experimental evidences intend to exhibit a direct involvement of mTOR (factor involved in protein synthesis) and an inhibitory effect on protein degradation via ubiquitin proteasome. The result of this modulation would therefore be a clear improvement in protein turnover.

Other studies, instead, underline the ability of HMB to reduce the activation of caspases, with consequent reduction of apoptotic processes, and to protect the cell from the oxidative insult mediated by ROS. This molecule is thus finding ample space in the treatment of all those diseases that induce cachexia (loss of lean mass), such as AIDS and cancer.

In sports, on the other hand, HMB is used both to improve body composition and to enhance athletic performance (strength and endurance)

Rational integration into HMB sports practice - 1000 Maximixe

As with most supplements on the market, there is an open debate on the ergo-genic effects of hydroxy methyl butyrate. Numerous studies show that supplementation with HMB, for about 4 weeks at 3 grams per day, can increase strength and reduce the feeling of fatigue in training, with a significant decrease in markers of muscle damage induced by physical activity. Others, however, support the hypothesis of the absence of ergogenic properties of this molecule.

From the careful re-reading of the various articles present in the literature, however, it is possible to draw some conclusions, albeit partial, given the scientific ignorance of the mechanism of action:

• Greater effectiveness in untrained individuals, for whom in addition to the aforementioned improvements, there has also been an increase in lean mass.
• Absence of beneficial effects derived from acute supplementation, and not protracted over time.

Recommended use by the company - HMB - 1000 Maximixe

It is advisable to take capsule daily with meals.

Use in HMB sports practice - 1000 Maximixe

The elective dosage appears to be that of 3 grams per day.

However, given the high individual variability, pharmacokinetic studies define a recommended dosage of 38mg / kg for at least 4 weeks. The various studies, in fact, seem to agree in considering the absence of ergo-genic effects in the short administration.

Given the dosage of this supplement, the standard 3 grams could be divided into 3 one-gram portions, thus reducing the renal clearance of this product.

It would be better, given the half-life of about 2.5h from its maximum peak, and the normalization of blood levels after 9 h, take one capsule in the morning, one immediately after training and another before going to bed.

How to optimize your HMB - 1000 Maximixe business

In the literature there are studies that show the effectiveness of HMB in synergy with glutamate and arginine, in improving protein turnover, and counteracting the cachectic effect manifested in some serious pathologies. A similar effect was observed on healthy and elderly individuals, after a year of supplementation with arginine, lysine and HMB.

The synergy between creatine and HMB seems instead ineffective.

Side effects HMB - 1000 Maximixe

The administration of HMB appears to be well tolerated at doses between 3 and 6 grams per day, and well documented in the literature even for several weeks of administration.

Animal studies also show how very high doses are tolerated.

A reduction in blood pressure was recorded in some studies following the administration of HMB, but this appears to be due to the presence of calcium in the product.

Precautions for use HMB - 1000 Maximixe

The product is contraindicated in cases of renal or hepatic disease, cardiovascular disease and / or hypertension, during pregnancy, during lactation, under 12 years and for adolescents not yet trained.

In the event of prolonged use (over 6/8 weeks), medical advice is required.

This article, elaborated on the critical re-reading of scientific articles, university texts and common practice, is for informational purposes only and is therefore not a medical prescription. It is therefore always necessary to consult your doctor, nutritionist or pharmacist before starting to use any kind of supplement . Further information on the critical analysis of HMB - 1000 Maximixe.

BIBLIOGRAPHY

The prevention and treatment of exercise induced muscle damage. Howatson G, van Someren KA. Sports Med. 2008; 38 (6): 483-503. Review. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation and promotion of muscle growth and strength. Slater GJ, Jenkins D. Sports Med. 2000 Aug; 30 (2): 105-16. Review. Beta-hydroxy-beta-Methylbutyrate and its use in athletics. Palisin T, Stacy JJ. Curr Sports Med Rep. 2005 Aug; 4 (4): 220-3. Review. Exercise-induced muscle damage is not attenuated by beta-hydroxy-beta-methylbutyrate and alpha-ketoisocaproic acid supplementation. Nunan D, Howatson G, van Someren KA. J Strength Cond Res. 2010 Feb; 24 (2): 531-7. Mechanism of attenuation by beta-hydroxy-beta-methylbutyrate of muscle protein degradation induced by lipopolysaccharide. Russell ST, Tisdale MJ. Mol Cell Biochem. 2009 Oct; 330 (1-2): 171-9. Epub 2009 Apr 30. Effects of nine weeks of beta-hydroxy-beta-methylbutyrate supplementation Thomson JS, Watson PE, Rowlands DS. J Strength Cond Res. 2009 May; 23 (3): 827-35. Effects of beta-hydroxy-beta-methylbutyrate supplementation during strength training, body composition, and muscle damage in trained and untrained young men: a meta-analysis. Rowlands DS, Thomson JS. J Strength Cond Res. 2009 May; 23 (3): 836-46. Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage. Wilson JM, Kim JS, Lee SR, Rathmacher JA, Dalmau B, Kingsley JD, Koch H, Manninen AH, Saadat R, Panton LB. Beta-hydroxy-beta-methylbutyrate supplementation reduces ex vivo tumor growth and tumor cell proliferation and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factor-kappaB expression. Nunes EA, Kuczera D, Brito GA, Bonatto SJ, Yamazaki RK, Tanhoffer RA, Mund RC, Kryczyk M, Fernandes LC. Nutr Res. 2008 Jul; 28 (7): 487-93. Effect of beta-hydroxy-beta-methylbutyrate (HMB) on protein metabolism in whole body and in selected tissues. Holecek M, Muthny T, Kovarik M, Sispera L. Food Chem Toxicol. 2009 Jan; 47 (1): 255-9. Epub 2008 Nov 21. Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review. Wilson GJ, Wilson JM, Manninen AH. Nutr Metab (Lond). 2008 Jan 3; 5: 1. J Appl Physiol. 1996 Nov; 81 (5): 2095-104. Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training. Int J Sport Nutr Exerc Metab. 2001 Dec; 11 (4): 442-50. Short-term beta-hydroxy-beta-methylbutyrate supplementation does not reduce symptoms of eccentric muscle damage. Paddon-Jones D, Keech A, Jenkins D. J Nutr Biochem. 2001 Nov; 12 (11): 631-639. beta-hydroxy-beta-methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humans. Effects of amino acids supplement on physiological adaptations to resistance training. Kraemer WJ, Hatfield DL, Volek JS, Fragala MS, Vingren JL, Anderson JM, Spiering BA, Thomas GA, Ho JY, Quann EE, Izquierdo M, Häkkinen K, Maresh CM. Med Sci Sports Exerc. 2009 May; 41 (5): 1111-21. Effects of six weeks of beta-hydroxy-beta-methylbutyrate (HMB) and HMB / creatine supplementation on strength, power, and anthropometry of highly trained athletes. O'Connor DM, Crowe MJ. J Strength Cond Res. 2007 May; 21 (2): 419-23. The effects of beta-hydroxy-beta-methylbutyrate (HMB) and HMB / creatine supplementation on indices of health in highly trained athletes. Crowe MJ, O'Connor DM, Lukins JE .. Effects of beta-hydroxy-beta-methylbutyrate and creatine monohydrate supplementation on the aerobic and anaerobic capacity of highly trained athletes. O'Connor DM, Crowe MJ. A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl beta-methyl butyrate, glutamine, and arginine mixture for the treatment of cancer cachexia (RTOG 0122). Berk L, James J, Schwartz A, Hug E, Mahadevan A, Samuels M, Kachnic L; RTOG. Support Care Cancer. 2008 Oct; 16 (10): 1179-88. Epub 2008 Feb 22. Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine. Baier S, Johannsen D, Abumrad N, Rathmacher JA, Nissen S, Flakoll P. JPEN J Parenter Enteral Nutr. 2009 Jan-Feb; 33 (1): 71-82.